Celecoxib ntụ ntụ

Kedu ihe bụ Celecoxib ntụ ntụ

Celecoxib ntụ ntụ bụ ọgwụ na-abụghị steroidal antiinflammatory (NSAID) nke mbụ ewepụtara dị ka Celebrex na US maka ọgwụgwọ nke mgbaàmà na ndị ọrịa nwere ọrịa ogbu na nkwonkwo (RA) na osteoarthritis (OA). Celecoxib bụ nke ọhụrụ klaasị 1, 5-diarylpyrazoles na ike synthesized site okpomọkụ na-akwalite heterocyclization nke trifiuoro-l,3-dione nwere arylhydrazine kwesịrị ekwesị. Celecoxib bụ onye na-egbochi COX-2 nke ukwuu, ụdị inducible nke cyclooxygenase gosipụtara n'oge usoro mkpali; ọ naghị egbochi ụdị ihe mejupụtara COX-1, si otú a na-egbochi nsị gastric na eriri afọ nke ọtụtụ NSAID ndị na-abụghị ndị a họọrọ. Oke ike COX1/COX2 na enzymes mmadụ dị ọcha bụ ihe dị ka 400. N'ọtụtụ ụdị vivo nke nnukwu na ọkụ na-adịghị ala ala, Celecoxib gosipụtara ọrụ mgbochi mkpali dị ike na-enweghị emetụta gastric ma ọ bụ urinary prostaglandin PGE2. N'ọtụtụ ọmụmụ ụlọ ọgwụ emere na ndị ọrịa na-arịa ọrịa ogbu na nkwonkwo ma ọ bụ ọrịa ogbu na nkwonkwo, Celecoxib gosipụtara na a nabatara ya nke ọma na iji belata ihe mgbu na mbufụt nke ọma ma e jiri ya tụnyere ọkọlọtọ NSAID ndị ọzọ; profaịlụ nchekwa eriri afọ dị mma karịa nke ndị NSAID ndị ọzọ. N'ụzọ na-akpali mmasị, a kwadoro Celecoxib maka ihe ngosi ọzọ na ndị ọrịa nwere ezinụlọ adenomatous polyposis (FAP). Nnwale ụlọ ọgwụ nke ọnwa isii gosipụtara mbelata 28% na ọnụ ọgụgụ nke polyps colorectal na Celecoxib, ma e jiri ya tụnyere mbelata 5% na placebo.

Coa nke Celecoxib ntụ ntụ

Kedu ọrịa nwere ike celecoxib ntụ ntụ a ga-eji gwọọ?

• Osteoarthritis na ọrịa ogbu na nkwonkwo.
• Mgbaàmà nke ankylosing spondylitis.
• Mmetụta analgesic na nnukwu, agafeghị oke na obere mgbu na nha nha nha, postoperative, isi dysmenorrhea, rheumatism anụ ahụ dị nro, wdg.
• Adenopathy nke ezinụlọ polyposis.

Kedu ihe mgbaàmà nwere ike iji celecoxib ntụ ntụ mee ka ọ kwụsịlata?

A na-ejikarị eme ihe iji belata mgbaàmà na ihe ịrịba ama nke osteoarthritis, na-ebelata ihe mgbu na isi dysmenorrhea.

Kedu ọgwụ ndị a na-ejikarị na celecoxib ntụ ntụ?

Ọrịa ogbu na nkwonkwo rheumatoid: Celecoxib nwere ike belata mgbaàmà mkpali na nnukwu ọkwa gout, mana ọ nweghị ike ikpochapụ ihe kpatara mbufụt. Ekwesịrị ijikọ ya na ọgwụ mgbochi ọrịa (gụnyere methotrexate, leflunomide, sulfasalazine, elamod, hydroxychloroquine, wdg) iji kpochapụ ihe kpatara ya ozugbo enwere ike.

Kedu onye amachibidoro iji ntụ ntụ celecoxib?

• Ndị mmadụ na-enwe nfụkasị na sulfonamides, NSAID ndị ọzọ ma ọ bụ ngwaahịa a.
• Ụmụ nwanyị dị ime na ndị na-enye nwa ara.
• Ndị mmadụ nwere akụkọ ihe mere eme nke infarction myocardial ma ọ bụ ọrịa strok.
• Ndị nwere nnukwu imeju na akụrụ mebiri.
• Ndị mmadụ nwere akụkọ ihe mere eme nke mmeghachi ahụ nfụkasị dị ka ihe mgbagwoju anya anaphylactic, ọkụ ọkụ, urticaria, angioedema, bronchospasm, na rhinitis siri ike ka amachibidoro iji celecoxib ntụ ntụ.

Kedu ọgwụ ndị celecoxib ntụ ntụ ga-emekọrịta ihe?

• Celecoxib ntụ ntụ jikọtara ya na aspirin yikarịrị ka ọ ga-ebute ọbara ọgbụgba nke eriri afọ karịa iji ngwaahịa a naanị, ya mere a ga-amachibido ya.
• CYP2C9 ntụ ntụ bụ metabolized nke CYP2C9, yabụ ndị na-egbochi CYP1CXNUMX dị ka fluconazole, zafirlukast na fluvastatin nwere ike igbochi metabolism ya ma mee ka itinye uche na ọgwụ ọbara ya dịkwuo elu. Fluconazole nwere ike iwelie mkpokọta ọgwụ ọbara nke celecoxib ntụ ntụ ihe dị ka otu ugboro; N'aka nke ọzọ, ndị na-emepụta enzyme imeju dị ka barbiturates ma ọ bụ rifampicin nwere ike ibelata mkpokọta ọgwụ ọbara nke celecoxib ntụ ntụ.
• Celecoxib ntụ ntụ nwere ike igbochi ọrụ nke CYP2C9, si otú ahụ na-amụba mkpokọta ọgwụ ọbara nke beta-receptor antagonists, antidepressants na antipsychotics metabolized site na enzyme a. Ya mere, ekwesịrị ịkpachara anya mgbe ejiri ngwaahịa a na ọgwụ ndị dị n'elu.
• Iji ya na antacids dị ka magnesium ma ọ bụ aluminom nwere ike ibelata nnabata ngwaahịa a.
• Celecoxib ntụ ntụ adịghị egbochi bioavailability na renal mkpochapụ nke methotrexate na ndị ọrịa nwere ọrịa ogbu na nkwonkwo.
• Celecoxib ntụ ntụ anaghị emekọ ihe na phenytoin sodium, tolbutamide, na glibenclamide.
• Ekwesịrị iji nlezianya nyochaa mmetụta anticoagulant n'ime ụbọchị ole na ole mbụ nke ijikọ ọnụ nke celecoxib ntụ ntụ na warfarin ma ọ bụ ọgwụ mgbochi ndị ọzọ, ma ọ bụ mgbe agbanwere dose nke ngwaahịa a.
• Celecoxib ntụ ntụ nwere ike ime ka ntinye ọbara nke nkwadebe lithium dịkwuo elu, ya mere, ekwesịrị ịme nlezianya anya mgbe ejikọtara ha abụọ ma ọ bụ mgbe ewepụrụ ngwaahịa a mgbe ejiri ya ọnụ.

Ckọntaktị US

Ọ bụrụ n'ịchọrọ ịzụta Celecoxib ntụ ntụ biko kpọtụrụ anyị maka nkọwa ndị ọzọ iceyqiang@aliyun.com