Ezetimibe ntụ ntụ, Salispharm chepụtara ma wepụta ya, bụ ọgwụ sitere n'okike ejiri n'ichepụta ọgwụ na-arụtụ aka maka ilekọta ọkwa cholesterol n'ime ahụ. Ọ bụ ọcha na ntụ ntụ ntụ ntụ, nke a na-ahụ anya dị ka (3R,4S) - 1- (4-fluorophenyl) - 3- [(3S) - 3- (4-fluorophenyl) - 3-hydroxypropyl] -4- (4-). hydroxyphenyl) azetidin-2-otu. Ndozi ọgwụ a siri ike (Programming interface) na-ewere òkè dị ukwuu n'igbochi njigide cholesterol na tract digestive, si otú a na-eweda ọkwa cholesterol n'ozuzu ya na sistem ọbara.
Salispharm na-etinye nnukwu ego n'ịbụ onye ọkachamara na-eweta ihe ndị na-emechabeghị ọgwụ, gụnyere ngwaahịa ahụ. Site na nka na ahụmịhe anyị sara mbara, anyị na-akwado usoro nha dị iche iche, na-ekwe nkwa myirịta na atụmatụ ọgwụ dị iche iche. Ma ọ bụ mbadamba nkume, ikpe, ma ọ bụ nkwusioru, Salispharm na-enye ọkaibe ngwaahịa ngwaahịa dabara adaba iji gboo ihe ndị ahịa anyị chọrọ.
Salispharm kwụpụrụ dị ka mkpebi a masịrị maka inweta ezetimibe ntụ ntụ n'ihi ihe ole na ole doro anya:
Nkebi | Nkọwapụta | IHE |
---|---|---|
ọdịdị | Ọcha ma ọ bụ na-acha ọcha ntụ ntụ, enweghị isi | Kwuru |
Identification | Site na IR | Kwuru |
Nke HPLC | Kwuru | |
Ntụgharị akọwapụtara | +13°~+18° | + 16.6 Celsius |
Ọdịnaya Mmiri (KF) | ≤0.50% | 0.07% |
Fọduru na mgbanye | ≤0.20% | 0.08% |
Vygba Elu | ≤20ppm | Kwuru |
Ihe ndozi | Ethanol: ≤5000ppm | 700ppm |
DMF: ≤880ppm | ND | |
Dichloromethane: ≤600ppm | ND | |
Toluene: ≤890ppm | ND | |
mmanya isopropyl: ≤5000ppm | ND | |
Ihe ndị emetụtara | Otu adịghị ọcha kacha elu: ≤0.10% | 0.04% |
Mkpokọta adịghị ọcha:≤1.00% | 0.12% | |
nnwale | 98.0% ~ 102.0% | 99.94% |
Ezetimibe 10 mg A na-egosipụta nke ọma maka nchịkwa hypercholesterolemia, karịsịa na ndị ọrịa nwere hypercholesterolemia dị mkpa ma ọ bụ hyperlipidemia agwakọta. A na-akwado ya mgbe niile dị ka onye inyeaka maka mgbanwe nri na cholesterol ndị ọzọ na-eweda ọgwụ, dị ka statins, iji mezuo njikwa lipid dị mma. Site na igbochi nnabata nke cholesterol n'ime nri, ngwaahịa a na-ebelata ọkwa lipoprotein cholesterol dị ala (LDL-C), yabụ na-eweda ịgba chaa chaa nke oge obi na ịrụ ọrụ na ahụike obi n'ozuzu ya.
Ọzọkwa, enwere ike ịkwado ngwaahịa a maka ọgwụgwọ hypercholesterolemia homozygous familial hypercholesterolemia, ọnọdụ ihe nketa na-adọrọ mmasị nke gosipụtara ọkwa LDL-C kachasị elu.
Ihe atụ aro nke Ezetimibe 1 mg mbadamba mgbanwe na-adabere n'otu akara, njirimara onye ọrịa, na ịga ọgwụ. Dị ka ọ na-adịkarị, a na-achịkwa ya n'ọnụ otu ugboro kwa ụbọchị, n'agbanyeghị nri. Ndị ọkachamara n'ịgwọ ahụike nwere ike gbanwee dose ahụ n'ihi mmeghachi omume n'otu n'otu na ebumnuche ọgwụgwọ.
Ọ dị mkpa ịrapara na usoro akwadoro na ụkpụrụ nhazi nke ndị na-ebubata nlekọta ahụike nyere. Ekwesịrị ka ejiri ngwaahịa a mee ihe dị ka akụkụ nke atụmatụ ọgwụgwọ dị anya nke na-agụnye mgbanwe nri na ụzọ ndụ mgbasa ozi iji rụpụta nsonaazụ enyemaka dị mma.
Salispharm na-ekwe nkwa ịdịmma na nchekwa nke ngwaahịa site na nrube isi na ụkpụrụ na nkwenye nke ọma, gụnyere:
Affirmations ndị a na-akwado ọrụ anyị ibuga ọgwụ unrefined components nke kasị mma, na-egbo mkpa siri ike nke ndu ọkachamara na ụlọ ọrụ ụkpụrụ.
Ezetimibe ntụ ntụ A na-ejikọta ya nke ọma dị ka usoro kachasị mma nke ụlọ ọrụ si eme iji kwe nkwa nkwanye ùgwù na ntụkwasị obi ya n'oge njem na ikike. Anyị na-eji nchekwa ma na-agbanwe ihe mkpokọ doro anya iji kpuchido ngwaahịa ahụ pụọ na mgbanwe eke na mmetọ.
Netwọk arụmọrụ anyị na-arụkọ ọrụ na-arụ ọrụ na njem kwesịrị ekwesị na nke a pụrụ ịdabere na ya, ma mpaghara ma n'ụwa nile. Anyị na ndị ọrụ ụgbọ njem nwere ntụkwasị obi na-arụkọ ọrụ iji kwe nkwa ibuga ndị ahịa anyị gburugburu ụwa n'ụzọ dị mma ma dị mfe.
Maka ozi ndị ọzọ gbasara ngwaahịa ahụ na ihe ndị ọzọ emechabeghị ọgwụ nke Salispharm gosipụtara, jiri obiọma kpọtụrụ anyị iceyqiang@gmail.com. Otu anyị raara onwe ya nye lekwasịrị anya n'inye enyemaka ahaziri iche na ilekọta arịrịọ ọ bụla ma ọ bụ ihe achọrọ maka ntinye akwụkwọ ngwa ngwa. Anyị na-atụ anya ijere mkpa ọgwụ gị nweta mkpa yana ịtọpụta mkpakọrịta na-eritekarị uru.