Finasteride bụ ngwakọta nke 4-azasteroid. Ọ bụ ihe mgbochi kpọmkwem nke ụdị intracellular enzyme ụdị II 5a-reductase na usoro nke testosterone metabolism n'ime dihydrotestosterone. Ọ nwere ike belata dihydrotestosterone nke ọma n'ime ọbara na prostate, ya bụ, site na igbochi ntụgharị nke testosterone n'ime dihydrotestosterone (DHT), ụda prostate na-ebelata, a na-emeziwanye ihe mgbaàmà, mmụba nke mmamịrị na-abawanye, ma na-egbochi hyperplasia prostate benign.
Finasteride bụ ogige 4-azasteroid nke bụ ihe mgbochi kpọmkwem nke intracellular enzyme ụdị II 5a-reductase na usoro nke testosterone metabolism n'ime dihydrotestosterone dị ike karị. Hyperplasia na-adịghị mma, ma ọ bụ prostate hypertrophy, na-adabere na ntụgharị nke testosterone na dihydrotestosterone na prostate. Ọgwụ a dị nnọọ irè n'ibelata dihydrotestosterone n'ime ọbara na prostate. Finasteride enweghị njikọ maka ndị na-anabata androgen.
Na nyocha ogologo oge na nchekwa nchekwa nke ọgwụ a (PLESS), ndị ọrịa 3016 nwere oke mgbaàmà nke hyperplasia prostate nke were ọgwụ a maka afọ 4 maka ọgwụgwọ usoro urinary nke metụtara prostate hyperplasia (ịwa ahụ), dị ka transurethral resection nke prostate na ndị ọzọ prostatectomies, ma ọ bụ nnukwu mmamiri njide chọrọ catheterization. N'ime nke a okpukpu abụọ kpuru ìsì, randomized, placebo na-achịkwa multicenter ọmụmụ, ọgwụgwọ na ọgwụ a belatara mkpokọta ihe ize ndụ nke usoro urinary usoro site 51%, na-esonyere dị ịrịba ama na-adịgide adịgide mbelata na prostate olu, nakwa dị ka nọgidere na-abawanye na kacha elu mmamịrị ọnụego. na mmụba nke mgbaàmà.
Finasteride bụ 4-nitrogen steroid compound na otu ụdị II 5a-reductase inhibitor. Ọ na-egbochi ntụgharị nke testosterone peripheral n'ime dihydrotestosterone ma belata ọkwa dihydrotestosterone n'ime ọbara, prostate, akpụkpọ anụ na anụ ndị ọzọ. Uto, mmepe na hyperplasia na-adịghị mma nke prostate na-adabere na dihydrotestosterone. Finasteride na-egbochi hyperplasia prostate ma na-emezi mgbaàmà ahụike metụtara hyperplasia prostate benign site na ibelata ọkwa dihydrotestosterone n'ime ọbara na prostate anụ ahụ.
COA nke Finasteride ntụ ntụ
analysis | nkọwapụta | N'ihi | Ule nnwale |
---|---|---|---|
ọdịdị | White ntụ ntụ | White ntụ ntụ | visual |
isi | e ji mara | e ji mara | Organoleptic |
urughuru size | 90% gafere 80 ntupu | 90% gafere 80 ntupu | 80 Mesh ihuenyo |
Nyocha (Lutein) | 98% | 98.15% | HPLC |
Loss na ihicha | 5.0% Max | 1.82% | 5g/105ºC/2 elekere |
Ọdịnaya Ash | 5.0% Max | 1.12% | 2g/525ºC/3 elekere |
Ihe ndozi | 50.0 ppm, naanị ethanol | <30.0 ppm | / |
arọ ọla | 5.0 ppm Max | <3.0 ppm | AAS |
ụzọ | 3.0 ppm Max | <1.0 ppm | AAS |
arsenic | 3.0 ppm Max | <1.0 ppm | AAS |
Ngụkọta ọnụ ọgụgụ nje bacteria | 1,000cfu / g Max | <280cfu/g | AOAC |
Yist & ebu | 100cfu / g Max | <10cfu/g | AOAC |
Ngwakọta | 30.0 MPN/g Max | <3.0 MPN/g | AOAC |
A na-ewere Proscar ọnụ, 5 mg / oge, otu ugboro kwa ụbọchị. 5 mg / ụbọchị, enwere ike were n'ụtụtụ na mgbede, tupu nri, na mgbe nri gasịrị. A na-atụ aro ka ị were ya ogologo oge.
Ndị ọrịa nwere ụkọ akụrụngwa: Achọghị mmezi usoro onunu ogwu maka ndị ọrịa nwere ogo dị iche iche nke ụkọ akụrụ (nchịkọta creatinine dị obere ka 9 ml / min).
Ndị okenye: Ọmụmụ ọgwụ na-agwọ ọrịa na ndị ọrịa karịrị afọ 70 egosila na ọnụ ọgụgụ nkwụsị nke finasteride na-ebelata, ma ọ dịghị mgbanwe usoro ọgwụgwọ achọrọ.
Mgbe a na-eji finasteride mee ihe maka ọgwụgwọ ntutu isi, a na-ewere ya 1 mg / oge, otu ugboro / ụbọchị, na usoro ọgwụgwọ 1 bụ ọnwa 4.
At Salispharm, Anyị na-elekwasị anya na enweghị nsogbu ọ bụla bundling nke anyị ihe na-ekwe nkwa ha nkwanye ùgwù n'oge njem. A na-akwaju ya nke ọma dịka ntuziaka ụlọ ọrụ siri dị iji gbochie mmetọ yana ijigide ihe nkwụsi ike. Anyị na-enye ụdị nhọrọ dị iche iche iji manye mkpa na ọchịchọ dị iche iche nke ndị ahịa. Netwọk usoro anyị dị irè na-enye ikike ibugharị iwu ngwa ngwa na ntụkwasị obi maka mmegide gburugburu ụwa, na-ekwe nkwa mbufe dị mma yana iguzosi ike n'ihe nke ndị ahịa.
Ọ bụrụ n'ịchọrọ ịzụta Finasteride ntụ ntụ biko kpọtụrụ anyị maka nkọwa ndị ọzọ iceyqiang@aliyun.com