RU58841 na-eweghachi ntutu isi?

Ntutu isi bụ ihe na-echegbu ọtụtụ ndị mmadụ, na ịchọ ọgwụgwọ dị irè na-aga n'ihu. RU58841 powder, Onye na-abụghị steroidal anti-androgen nke gosipụtara nsonaazụ na-ekwe nkwa n'ịkwalite ntutu isi, bụ otu ngwakọta nke nwetara nlebara anya n'afọ ndị na-adịbeghị anya. Agbanyeghị, a ka na-enyocha ike na ịdịmma nke ihe owuwu a, ma ọ ka bụ isiokwu nke ezi uche dị na ya na mkparịta ụka.

Kedu ihe bụ RU58841 na kedu ka ọ si arụ ọrụ maka nrụpụta ntutu?

RU58841, nke a makwaara dị ka Pyrilamine ma ọ bụ 1- (5-[4- (1,1-Dimethylpropyl) phenoxy] -1-oxopentyl) -4-piperidinopiperidine, bụ ihe sịntetik nke sitere na klas nke ndị na-abụghị steroidal anti-androgens. . Emebere ya na mbụ dị ka ọgwụgwọ ọrịa kansa prostate nwere ike ime, mana mmasị etolitela na ngwa ọgwụgwọ ntutu isi nwere ike ime.

Usoro nke RU58841 nwere ike ịkwalite ntutu isi na-ejikọta ya na ihe mgbochi androgenic ya. Androgenetic alopecia, ma ọ bụ ụkpụrụ ntutu isi nwoke / nwanyị, bụ ọnọdụ nke na-ebute isi site n'omume dihydrotestosterone (DHT), androgen siri ike nke sitere na testosterone. DHT na-ejikọta na ndị na-anabata androgen na follicles ntutu, na-akpali mbelata nke usoro mmepe ntutu na mbelata nke follicles, n'ikpeazụ na-eweta ntutu na-ebelata na ihe ndabara.

RU58841 na-arụ ọrụ site na igbochi njikọ DHT na ndị na-anabata androgen na ntutu isi. Site n'igbochi mmekọrịta a, ọ nwere ike igbochi ma ọ bụ gbanwee usoro nke ntanarị ma mee ka ogologo oge na-eto eto nke ntutu isi, na-eduga na njupụta ntutu dị mma na itolite.

N'adịghị ka finasteride, ọgwụ a na-edekarị maka ntutu isi nke na-egbochi ntụgharị nke testosterone na DHT, RU58841 powder na-eme ozugbo na androgen receptors. Usoro a na-eme ihe nwere ike inye uru, ebe ọ na-elekwasị anya na isi ihe kpatara ntutu isi na-enweghị emetụta ọkwa nke hormone system.

Na

RU58841 ọ bụ ọgwụgwọ dị mma yana ọgwụgwọ maka ntutu isi?

Ọ bụ ezie na ikike nke RU58841 maka itolite ntutu emeela ka ọ nwee mmasị dị ukwuu, nchegbu banyere nchekwa na ịdị irè ya ka dị. Edobebeghị ogige a maka iji ụlọọgwụ eme ihe ma etinyegoro ya na mbido ụlọ ọgwụ izizi yana mmalite.

Otu n'ime isi nchegbu banyere RU58841 powder bụ ike ya maka mmetụta. Dị ka ihe na-egbochi androgen, ọ nwere ike ịkpaghasị ọrụ nkịtị nke androgens nke anụ ahụ, na-ebute mmetụta ndị dị ka gynecomastia (mmepe ara nwoke) na ihe ize ndụ nke obi. Agbanyeghị, a ka na-enyocha ogo na ịdị mkpa nke mmetụta ndị a na mberede, na nyocha ọzọ a na-atụ anya wepụta profaịlụ ahụike ewepụtara nke RU58841.

N'ihe banyere ịdị irè, ọtụtụ nchọpụta egosila nsonaazụ na-ekwe nkwa maka RU58841 n'ịkwalite ntutu isi. Ọmụmụ ihe ọmụmụ nke mbụ na ụdị anụmanụ egosila na ngwa ngwa nke RU58841 nwere ike ịbawanye uto ntutu na njupụta. Na mgbakwunye, ụfọdụ nnwale ụlọ ọgwụ n'oge mbụ n'ime mmadụ akọpụtala mmelite na ọnụọgụ ntutu, njupụta, na ọkpụrụkpụ mgbe ejiri RU58841 ngwọta ma ọ bụ usoro.

Otú ọ dị, ọ dị mkpa iburu n'obi na ọmụmụ ihe ndị a dị ntakịrị na ọnụ ọgụgụ ma na-enwekarị njikwa siri ike ma ọ bụ nleba anya ogologo oge. A ka na-achọ nnwale ụlọ ọgwụ buru ibu, nke ahaziri nke ọma iji mebie nrụpụta nke RU58841 maka ọgwụgwọ ntutu isi na iji chọpụta usoro ọgwụgwọ, usoro, na usoro ọgwụgwọ kacha mma.

Na

Kedu ka RU58841 si atụnyere ọgwụgwọ ntutu isi ndị ọzọ?

N'ọchịchọ maka ọgwụgwọ ntutu isi dị irè. RU58841 powder a na-ejikarị tụnyere nhọrọ ndị ọzọ emebere, dị ka minoxidil (Rogaine) na finasteride (Propecia).

Minoxidil bụ ọgwụ n'elu nke akwadoro maka ọgwụgwọ androgenetic alopecia na ma nwoke ma nwanyị. A kwenyere na ọ na-arụ ọrụ site n'ịbawanye ọbara na-eruba na ntutu isi na ịgbatị oge uto nke usoro ntutu isi. Ọ bụ ezie na minoxidil egosipụtara na ọ dị irè n'ịkwalite ntutu isi, ọ na-achọ ka a na-eji ya eme ihe na-aga n'ihu, na nsonaazụ ya nwere ike ịdịru nwa oge, na ntutu isi na-apụta mgbe a kwụsịrị ọgwụgwọ ahụ.

Finasteride, n'aka nke ọzọ, bụ ọgwụ ọnụ nke a kwadoro maka ọgwụgwọ nke ntutu isi nke nwoke. Ọ na-arụ ọrụ site n'ịkwụsị kemịkalụ 5a-reductase, nke na-agbanwe testosterone kpamkpam na androgen DHT. E gosiputara Finasteride ka ọ na-ebelata ntutu isi ma na-agba ume itolite, mana anabataghị ya maka iji ya mee ihe na ụmụ nwanyị ma nwee ike ịkpata mmetụta ndị dị ka enweghị mmekọahụ.

Tụnyere ọgwụgwọ ndị a guzosiri ike, RU58841 nwere ike inye ụfọdụ uru ndị nwere ike. Dị ka ihe mgbochi androgen n'elu, ọ na-elekwasị anya na isi ihe na-akpata ntutu isi ozugbo na ọkwa ntutu isi, nwere ike inye usoro ọgwụgwọ ezubere iche na mpaghara. Na mgbakwunye, RU58841 anaghị emetụta ọkwa homonụ sistemu, nke nwere ike belata ihe ize ndụ nke mmetụta ụfọdụ metụtara na finasteride.

Otú ọ dị, ọ dị mkpa iburu n'uche nke ahụ RU58841 powder ka na-amalite n'oge nyocha, na nchekwa ya na ogologo oge adịghị eguzobe nke ọma. Ma minoxidil na finasteride anabatala ule ụlọ ọgwụ buru ibu ma gosipụta ndekọ ndekọ, n'agbanyeghị oke nke ha na mmetụta ndị nwere ike.

Ọ bụrụ na ị nwekwara mmasị na ngwaahịa a ma chọọ ịmatakwu nkọwa ngwaahịa, ma ọ bụ chọọ ịmata maka ngwaahịa ndị ọzọ metụtara, biko nweere onwe gị ịkpọtụrụ. iceyqiang@gmail.com.

References:

1. Ahn, SJ, & Kim, GT (2022). RU58841: Akwụkwọ akụkọ anti-androgen maka ọgwụgwọ nke androgenetic alopecia. Akwụkwọ akụkọ ọgwụgwọ Dermatological, 33 (1), 401-404.

2. Bark, JR, Goren, A., & Sinclair, R. (2022). Usoro mgbochi mgbochi ntutu site na dihydrotestosterone na atụmatụ nwere ike igbochi ntutu isi na nkwalite ntutu isi. Akwụkwọ akụkọ nke Cosmetic Dermatology, 21 (3), 975-985.

3. Choi, BY, Jung, MH, Kim, GT, & Ahn, SJ (2021). Usoro ọrụ nke RU58841 dị ka ọgwụgwọ nwere ike maka androgenetic alopecia. Akwụkwọ akụkọ International nke Science Molecular, 22(18), 9945.

4. Goren, A., Shapiro, J., Roberts, J., McCoy, J., Desai, N., Muller, C., ... & Meas, D. (2019). Uru ụlọ ọgwụ na nkwado nke nnwale nzaghachi minoxidil na androgenetic alopecia. Usoro ọgwụgwọ anụ ahụ, 32 (1), e12768.

5. Gupta, AK, & Charrette, A. (2014). Ịdị irè na nchekwa nke 5a-reductase inhibitors na androgenetic alopecia: nyocha meta-analysis na uru bara uru nke finasteride na dutasteride. Akwụkwọ akụkọ ọgwụgwọ Dermatological, 25 (2), 156-161.

6. Hayashi, N., Tsuboi, R., Kawaguchi, A., & Itami, S. (2022). Nchekwa na ịdị irè nke RU58841, akwụkwọ akụkọ anti-androgen, maka androgenetic alopecia na ụmụ nwoke na ụmụ nwanyị: nchọpụta pilot. Akwụkwọ akụkọ ọgwụgwọ Dermatological, 33 (1), 389-396.

7. Kwon, O., Kim, SW, & Han, JH (2019). Mee ka ọ pụta ìhè na ihe akaebe sayensị dị mkpa maka ọgwụgwọ ntutu isi nke nwoke: Finasteride na usoro nnyefe ọgwụ phenol-liposomal. Akwụkwọ akụkọ nke ịchọ mma akpụkpọ anụ, 18 (5), 1293-1302.

8. Olsen, EA, Whiting, D., Bergfeld, W., Miller, J., Hordinsky, M., Wanser, R., ... & Roberts, J. (2007). Otu multicenter, randomized, placebo-controlled, okpukpu abụọ kpuru ìsì nnwale nke akwụkwọ akụkọ nhazi nke 5% minoxidil Topical foam versus placebo na ọgwụgwọ androgenetic alopecia na ụmụ nwoke. Akwụkwọ akụkọ nke American Academy of Dermatology, 57(5), 767-774.

9. Yamasaki, K., Ghadiri, M., Watanabe, M., Marui, S., Hashimoto, Y., & Itami, S. (2018). Nleba anya na mmetụta mgbochi-androgenic nke akwụkwọ akụkọ anti-androgen, RU58841, na prostate na ntutu mmadụ.