Kedu ka Metronidazole ntụ ntụ si arụ ọrụ?

Metronidazole bụ ọgwụ nje na antiprotozoal a na-ejikarị eme ihe nke ejirila na-agwọ ọrịa nje na nje nje dị iche iche kemgbe ọtụtụ iri afọ. Otu n'ime ụdị ọgwụ a na-ahụkarị bụ metronidazole ntụ ntụ, nke a na-ejikarị eme ihe n'ịgbakọta ụlọ ahịa ọgwụ ma ọ bụ maka ebumnuche ọgwụgwọ anụmanụ. Ịghọta otú nhazi ntụ ntụ a si arụ ọrụ dị oké mkpa maka ijide n'aka na ojiji ya dị mma ma dị irè.

Kedu ihe bụ Metronidazole ntụ ntụ na kedu ka esi emepụta ya?

Metronidazole ntụ ntụ bụ ihe dị mma, kristal nke na-acha ọcha ma ọ bụ na-acha ọcha na agba. A na-emepụta ya site na micronization nke ọgwụ na-arụ ọrụ, metronidazole, ka ọ bụrụ ntụ ntụ. Enwere ike iji ntụ ntụ a mee ihe n'ụdị dị iche iche, dị ka ọgwụ na-agbakọta, ịkwadebe ihe ngwọta n'elu, ma ọ bụ maka iji ya mee ihe na ọgwụgwọ ọrịa anụmanụ.

Nhazi nke metronidazole ntụ ntụ gụnyere ọtụtụ usoro, gụnyere:

1. Micronization: The metronidazole nọ n'ọrụ mgwa bụ micronized, ma ọ bụ belata na ezi ahụ, na-eji pụrụ iche ngwá dị ka jet igwe ma ọ bụ bọọlụ igwe. Usoro a na-eme ka akụkụ elu nke ọgwụ ahụ dịkwuo elu, nke nwere ike imezi mgbasa ya na absorption n'ime ahụ.

2. Ịgwakọta: A na-ejikọta ntụ ntụ metronidazole nke micronized na ihe ndị ọzọ na-emepụta ihe, dị ka ndị na-ejuputa, ihe nkedo, ma ọ bụ lubricants, iji mepụta ngwakọta na-ejikọta ọnụ. Ihe ndị a agbakwunyere nwere ike inye aka melite nrịba nke ntụ ntụ, mkpakọ, na nkwụsi ike.

3. Nkwakọ ngwaahịa: A na-akwakọba ntụ ntụ metronidazole na arịa kwesịrị ekwesị, dị ka karama ma ọ bụ akpa, iji chebe ya pụọ ​​na ihe ndị dị na gburugburu ebe obibi dị ka mmiri, ọkụ, na mmetọ.

The kpọmkwem nhazi na mejupụtara nke metronidazole ntụ ntụ nwere ike ịdị iche dabere na ebumnuche ebumnuche yana ihe ndị nrụpụta chọrọ.

Kedu ka Metronidazole ntụ ntụ si arụ ọrụ n'ime ahụ?

Metronidazole, ihe na-arụ ọrụ na ntụ ntụ, bụ ihe nitro-imidazole nke ejirila mee ihe maka ọgwụgwọ ọrịa nje anaerobic dị iche iche na protozoal. Usoro nke metronidazole dị mgbagwoju anya ma na-agụnye ọtụtụ usoro:

1. Cellular Uptake: Metronidazole na-abanye ngwa ngwa site na eriri afọ ma ọ bụ ebe a na-etinye ya (dịka ọmụmaatụ, ngwa n'elu) wee banye n'ime sel ndị e lekwasịrị anya, gụnyere nje bacteria, protozoa, na ụfọdụ ụdị sel mmadụ.

2. Nrụ ọrụ: Ozugbo n'ime cell, metronidazole na-ebelata site na usoro nke gụnyere enzymes kpọmkwem ma ọ bụ usoro njem eletrik. Usoro mbelata a na-atụgharị metronidazole n'ụdị ya na-arụ ọrụ, nke a kwenyere na ọ bụ nitro radical ma ọ bụ ndị ọzọ na-emeghachi omume.

3. Mmebi DNA: Ụdị metronidazole na-arụ ọrụ nwere ike imekọrịta ma mebie DNA nke mkpụrụ ndụ ndị a na-eche, na-eduga n'ịgbaghasị ihe mkpụrụ ndụ ihe nketa ha na ọnwụ cell.

4. Mgbochi nke Ọrụ Cellular: Metronidazole nwekwara ike igbochi usoro cellular ndị ọzọ, dị ka njikọ protein na mmepụta ume, na-enye aka na mkpokọta antimicrobial na antiprotozoal mmetụta.

Nhọrọ nke metronidazole n'akụkụ ihe ndị dị ndụ anaerobic bụ n'ihi ụzọ metabolic pụrụ iche ha na ọnụnọ nke enzymes akọwapụtara nke nwere ike belata ma rụọ ọrụ ọgwụ ahụ. Nhọrọ a na-enyere aka ibelata mmetụta na sel mmadụ na anụ ahụ aerobic, na-eme ka metronidazole bụrụ ihe na-egbochi nje na-adịghị mma ma dị irè.

Kedu ihe bụ ngwa na ojiji nke Metronidazole ntụ ntụ?

Metronidazole ntụ ntụ nwere ọtụtụ ngwa na ojiji, ma na nkà mmụta ọgwụ mmadụ na ọgwụgwọ anụmanụ. Ụfọdụ ngwa igodo gụnyere:

1. Ngwakọta ọgwụ: Metronidazole ntụ ntụ na-ejikarị eme ihe n'ịgbakọta ụlọ ahịa ọgwụ iji kwadebe usoro ọgwụgwọ ahaziri iche, dị ka ude, gels, ma ọ bụ ngwọta. Nke a na-enye ndị na-ahụ maka ahụike aka ịhazi ọgwụ ahụ na mkpa ndị ọrịa ha chọrọ.

2. Ọgwụ ọgwụgwọ anụmanụ: Metronidazole ntụ ntụ bụ nke a na-ejikarị na ọgwụgwọ ọrịa anụmanụ maka ọgwụgwọ nke nje bacteria anaerobic na protozoal dị iche iche na anụmanụ, dị ka giardiasis, trichomoniasis, na ụfọdụ ụdị ọrịa periodontal.

3. Ọgwụgwọ dị n'elu: Metronidazole ntụ ntụ enwere ike ịhazi ya n'ime nkwadebe dị n'elu, dị ka ude, ude, ma ọ bụ ihe ngwọta, maka ọgwụgwọ anụ ahụ na ọrịa anụ ahụ dị nro, gụnyere rosacea na nje vaginosis.

4. Nkwụsịtụ ọnụ: Metronidazole ntụ ntụ nwere ike iji dozie nkwụsịtụ ọnụ, nke nwere ike ịbụ ụdị ọgwụgwọ bara uru maka ndị ọrịa nwere nsogbu ilo mbadamba nkume ma ọ bụ capsules.

5. Nlekọta ọnya: Metronidazole ntụ ntụ nwere ike iji kwadebe uwe ma ọ bụ ngwa ngwa maka nlekọta nke ọnyá, karịsịa ndị nwere ọrịa nje anaerobic.

6. Nnyocha na mmepe: Metronidazole ntụ ntụ nwere ike iji mee nchọpụta na ntọala mmepe, dị ka maka ịmepụta ngwaahịa ọgwụ ọhụrụ ma ọ bụ nyocha nke pharmacokinetic na pharmacodynamic ọgwụ.

Ntughari nke metronidazole ntụ ntụ na-enye ndị ọkachamara ahụike aka ịhazi ọgwụ ahụ maka mkpa ndị ọrịa ha ma ọ bụ ebumnuche nyocha, na-eme ka ọ bụrụ ngwá ọrụ bara uru na njikwa nke ọtụtụ ọrịa na ọnọdụ.

mmechi

N'ikpeazụ, metronidazole ntụ ntụ bụ ọgwụ nje na ọgwụ antiprotozoal nke a na-ejikarị eme ihe na nke na-arụ ọrụ dị mkpa n'ịgwọ ọrịa nje na nje dị iche iche. Ịghọta usoro nhazi, usoro ihe omume, na ngwa nke nhazi ntụ ntụ a dị mkpa maka ndị ọkachamara ahụike iji hụ na ọ dị mma ma dị irè. Site leveraging pụrụ iche Njirimara nke metronidazole ntụ ntụ, ndị na-ahụ maka ahụike nwere ike ịnye ọgwụgwọ ahaziri iche na nke ezubere iche, n'ikpeazụ na-emeziwanye nsonaazụ ndị ọrịa.

Ọ bụrụ na ị nwekwara mmasị na ngwaahịa a ma chọọ ịmatakwu nkọwa ngwaahịa, ma ọ bụ chọọ ịmata maka ngwaahịa ndị ọzọ metụtara, biko nweere onwe gị ịkpọtụrụ. iceyqiang@aliyun.com.

References:

1. Amin, N., & Stuntz, M. (2021). Metronidazole. Na StatPearls. Mbipụta StatPearls.

2. Bharti, S., & Srivastava, A. (2020). Metronidazole: Pharmacology na ngwa ọgwụgwọ. Akwụkwọ akụkọ nke Clinical and Diagnostic Research, 14 (7), FE01-FE05.

3. Ụlọ Ọrụ Maka Nchịkwa na Mgbochi Ọrịa. (2022). Metronidazole.

4. Choi, JH, & Chung, JW (2019). Metronidazole: nyocha mmelite. Ebe nchekwa nke nyocha ọgwụ, 42(4), 337-353.

5. Erdman, SE, & Poutahidis, T. (2016). Probiotic 'ọkụ nke ahụike': ọ karịrị anụ ahụ miri emi. Microbes bara uru, 7 (2), 187-199.

6. Nchịkwa nri na ọgwụ. (2022). Metronidazole.

7. Hooton, TM (2018). Metronidazole maka ọgwụgwọ nke ikpu ọrịa. Akwụkwọ akụkọ American Journal of Medicine, 131 (6), 602-610.

8. Lessa, FC, Mu, Y., Bamberg, WM, Beldavs, ZG, Dumyati, GK, Dunn, JR, ... & McDonald, LC (2015). Ibu nke ọrịa Clostridium difficile na United States. Akwụkwọ akụkọ ọgwụ New England, 372 (9), 825-834.

9. Schepis, D., & Gittelman, R. (2019). Metronidazole: nyocha nke ojiji ya na dermatology. Cutis, 103 (3), 162-167.

10. Òtù Ahụ Ike Ụwa. (2021). Ndepụta Nlereanya WHO nke ọgwụ ndị dị mkpa.