Ekwenyere Semeglutide maka mbelata ibu?

Ọrịa oke ibu aghọwo nsogbu ahụike zuru ụwa ọnụ, na-akpali ndị nchọpụta na ndị ọkachamara ahụike ịchọ ọgwụgwọ dị irè. N'afọ adịbeghị anya, Semeglutide apụtala dị ka onye nwere ike ịgbanwe egwuregwu n'ọgụ megide oke ibu. N'ịbụ nke emepụtara dị ka ọgwụ maka ụdị ọrịa shuga 2, Semeglutide egosila nkwa dị ịrịba ama na inye aka belata ibu. Edemede a ga-abanye n'ọkwa nkwado nke Semeglutide maka oke ibu, nyochaa usoro omume ya, nyochaa ihe akaebe ụlọ ọgwụ na-akwado iji ya, wee kwurịta ihe nchekwa maka ngwa ogologo oge na njikwa ibu.

Olee otú Semeglutide Na-arụ ọrụ maka njikwa ibu?

Semeglutide bụ nke otu ọgwụ a maara dị ka glucagon-like peptide-1 (GLP-1) agonists nnabata. Ọ bụ ezie na e mere ya na mbụ iji wetulata ọkwa shuga dị n'ọbara n'ime ndị nwere ụdị ọrịa shuga 2, mmetụta ọ na-enwe na agụụ agụụ na mmefu ike etinyela ya n'isi n'ihu nyocha nke ịbelata ibu. Iji ghọta ka Semeglutide si arụ ọrụ maka njikwa ibu, ọ dị mkpa iji nyochaa mmetụta ya na ụzọ physiological dị iche iche:

1. Iwu agụụ: Semeglutide na-eṅomi omume GLP-1, hormone nke emepụtara na eriri afọ. Site n'ịgbalite ndị na-anabata GLP-1 na ụbụrụ, ọ na-enyere aka ibelata agụụ na ịbawanye mmetụta nke afọ ojuju. Mmetụta a nwere ike ibute mbelata dị ukwuu na oriri calorie, ihe dị mkpa na-ebelata ibu.

2. Ịkụfu afọ: Ọgwụ a na-ebelata ọsọ nke nri na-esi n'afọ pụta, na-eme ka mmetụta nke satiety dịkwuo ogologo ma e risịrị nri. Mwepu afọ a na-egbu oge na-atụnye ụtụ na mbelata oriri oriri ma na-enyere aka ijikwa ọkwa shuga dị n'ọbara.

3. Insulin secretion: N'ime ndị nwere ụdị ọrịa shuga 2, Semeglutide na-akpali ntọhapụ nke insulin site na mkpụrụ ndụ beta nke pancreatic na nzaghachi maka ọkwa glucose ọbara dị elu. Nke a na-eme ka mmetụta insulin dịkwuo mma nwere ike ịkwado mbọ ịbelata ibu ibu na-apụtaghị ìhè site n'ịkwalite ahụike metabolic ka mma.

4. Mmefu ike: Ụfọdụ ọmụmụ na-egosi na Semeglutide nwere ike ịbawanye mmefu ike, ọ bụ ezie na mmetụta a dị ntakịrị karịa mmetụta ọ na-enwe na agụụ. Aghọtachaghị usoro dị n'azụ nke a mana ọ nwere ike ịgụnye mgbanwe n'ọrụ anụ ahụ adipose aja aja.

5. Mmasị nri: N'ụzọ na-akpali mmasị, nchọpụta na-egosi na Semeglutide nwere ike imetụta nhọrọ nri, nwere ike ibelata agụụ maka nri ndị nwere abụba dị elu na ịbawanye mmasị maka nhọrọ calorie dị ala.

Site n'ịkwado ọtụtụ ụzọ ndị a, Semaglutide na-enye usoro zuru oke maka njikwa ibu nke na-agafe mmachi calorie dị mfe.

Kedu ihe bụ nsonaazụ ụlọ ọgwụ Semeglutide na Mbelata ibu?

Amụtala ịdị mma nke Semeglutide maka ịbelata ibu n'ọtụtụ nnukwu nnwale ụlọ ọgwụ. Ọmụmụ ihe ndị a enyela ihe akaebe na-adọrọ adọrọ nke na-emetụta mkpebi nchịkwa gbasara nkwenye ya maka nkwụsị ibu. Ka anyị leba anya n'ụfọdụ isi nchoputa:

1. STEP (Semeglutide Treatment Effect in People with Obesity) Mmemme: Usoro nnwale a zuru oke tụlere uru na nchekwa Semeglutide maka oke ibu na ndị mmadụ dị iche iche. Nnwale STEP 1, nke e bipụtara na New England Journal of Medicine, gosiri na ndị na-anata 2.4 mg kwa izu nke Semeglutide tụfuru nkezi nke 14.9% nke ịdị arọ ahụ ha n'ime izu 68, ma e jiri ya tụnyere 2.4% na placebo otu.

2. SUSTAIN (Semeglutide Unabated Sustainability in Treatment of Type 2 Diabetes) Nnwale: Ọ bụ ezie na isi lekwasịrị anya na njikwa ọrịa shuga, ule ndị a gosikwara uru mbelata ibu arọ. Dịka ọmụmaatụ, nnwale SUSTAIN 6 gosiri na Semeglutide butere mbelata ịdị arọ nke 4.3 n'arọ ruo 6.1 n'arọ, dabere na dose ahụ, karịa izu 104.

3. Nchikota na ntinye aka n'ụdị ndụ: Nnwale ụlọ ọgwụ egosila mgbe niile na arụ ọrụ Semeglutide na-abawanye mgbe ejikọtara ya na mgbanwe ndụ. Nnwale STEP 3, nke gụnyere ọgwụgwọ omume kpụ ọkụ n'ọnụ na nri nwere obere kalori, kọrọ na nkezi ịdị arọ nke 16.0% Semeglutide otu tụnyere 5.7% na placebo otu.

4. Ọmụmụ ihe atụnyere: Nnyocha atụnyere Semeglutide na ọgwụ ndị ọzọ na-efunahụ ibu achọpụtala na ọ dị irè karị. Dịka ọmụmaatụ, ọmụmụ na-atụnyere Semeglutide na liraglutide (onye ọzọ GLP-1 agonist receptor) gosipụtara nsonaazụ oke ibu na Semeglutide.

5. Ogologo Ogologo Ogologo oge: Nnwale STEP 5, nke dịruru afọ abụọ, gosipụtara na mbelata arọ nke Semeglutide nwetara nwere ike ịnọgide na-adị ogologo oge, na ndị na-eso ya na-ejigide ihe dị arọ nke 15.2% na njedebe nke ọmụmụ. .

Nsonaazụ nnwale ụlọ ọgwụ ndị a dị egwu bụ ihe dị mkpa na usoro nnabata nke Semeglutide dị ka ọgwụ na-efunahụ ibu. Na June 2021, US Food and Drug Administration (FDA) kwadoro Semeglutide (n'okpuru akara aha Wegovy) maka nlekọta ịdị arọ na-adịghị ala ala na ndị okenye nwere oke ibu ma ọ bụ oke ibu nwere opekata mpe otu nsogbu metụtara ibu. Nkwenye a dabere na ike nke ihe akaebe sitere na mmemme nnwale ụlọ ọgwụ STEP.

Is Semeglutide Ọ dị mma maka njikwa mbelata ibu ogologo oge?

Ọ bụ ezie na ikike nke Semeglutide maka ịbelata ibu na-atọ ụtọ, nchekwa bụ ihe kachasị mkpa, ọkachasị maka iji ogologo oge. A tụlere profaịlụ nchekwa nke Semeglutide nke ọma na nnwale ụlọ ọgwụ yana nleba anya mgbe ahịa gasịrị:

1. Mmetụta Na-emekarị: Mmetụta ndị a na-akọkarị nke Semeglutide bụ eriri afọ na ọdịdị, gụnyere ọgbụgbọ, vomiting, afọ ọsịsa, na afọ ntachi. Mmetụta ndị a na-adịkarị nwayọọ ma na-agafeghị oke ma na-ebelata ka oge na-aga ka ahụ na-emeziwanye ọgwụ ahụ.

2. Ihe omume ọjọọ na-adịghị ahụkebe ma dị oke njọ: Mmetụta dị njọ karịa, ọ bụ ezie na ọ dị ụkọ, akọpụtala. Ndị a na-agụnye pancreatitis, nsogbu gallbladder, na mgbanwe nke ọnụọgụ obi. Ihe ize ndụ nke ụbụrụ C-cell thyroid, nke a na-ahụ na ọmụmụ anụmanụ, edugawo ịdọ aka ná ntị igbe, ọ bụ ezie na ekwenyebeghị ihe ize ndụ a na ụmụ mmadụ.

3. Data nchekwa ogologo oge: Nnwale STEP 5 nyere nghọta bara uru na nchekwa ogologo oge nke Semeglutide maka njikwa ibu. N'ime afọ abụọ ọmụmụ ihe, profaịlụ nchekwa nọgidere na-adaba na mbụ, obere oge ule, na-enweghị ọhụrụ nchekwa nchegbu na-apụta.

4. Mmekọrịta ọgwụ: Semeglutide nwere ike iji ọgwụ ndị ọzọ na-emekọrịta ihe, ọkachasị ndị na-emetụta ọkwa shuga dị n'ọbara. Ọ dị mkpa maka ndị na-ahụ maka ahụike ka ha nyochaa ndepụta ọgwụ zuru oke nke onye ọrịa tupu ha edepụta Semeglutide.

5. Ndị Pụrụ Iche: Nchekwa Semeglutide n'ime ime, inye nwa ara, na ọnụ ọgụgụ ụmụaka eguzobebeghị, a naghị atụ aro iji ya mee ihe na otu ndị a.

6. Mmetụta nkwụsị: Ụfọdụ nnyocha achọpụtala na ị nwetaghachi ibu nwere ike ime mgbe ịkwụsị Semeglutide, na-akọwapụta mkpa nke atụmatụ ọgwụgwọ ogologo oge na mgbanwe ndụ.

Iji hụ na iji Semeglutide dị mma ma dị mma maka njikwa oke ibu, ewepụtala ntuziaka:

• Nhọrọ onye ọrịa: A na-egosi Semeglutide maka ndị okenye nwere BMI nke 30 kg/m² ma ọ bụ karịa (oke ibu) ma ọ bụ 27 kg/m² ma ọ bụ karịa (oke ibu) na ọnụnọ opekata mpe otu nsogbu metụtara ibu.
• Usoro nhazi usoro: A na-amalitekarị ọgwụ ahụ na obere dose ma jiri nwayọọ nwayọọ na-abawanye n'ime izu ole na ole iji belata mmetụta ndị ọ na-enwe.
• Nleba anya: A na-atụ aro nhọpụta ndị na-esochi mgbe niile iji chọpụta ọganihu, jikwaa mmetụta ndị na-adịghị mma, na dozie ọgwụgwọ dịka ọ dị mkpa.
• Ngwakọta ya na mgbanwe ụdị ndụ: Semeglutide ekwesịrị iji ya na nri calorie belatara yana mmega ahụ na-abawanye maka nsonaazụ kacha mma.
• Contraindications: A na-egbochi ọgwụ ahụ na ndị ọrịa nwere akụkọ ihe mere eme nke onwe ma ọ bụ ezinụlọ nke medullary thyroid carcinoma ma ọ bụ na ndị ọrịa nwere ụdị ọrịa Multiple Endocrine Neoplasia syndrome 2.

mmechi

Njem Semeglutide site na ọgwụ ọrịa shuga gaa na ọgwụgwọ mbelata oke ibu na-anọchite anya ọganihu dị ukwuu na ngalaba ọgwụgwọ oke ibu. Nsonaazụ nnwale ụlọ ọgwụ siri ike, na-egosipụta nnukwu ibu ma na-adịgide adịgide, yana profaịlụ nchekwa zuru oke, etinyela Semeglutide dị ka ngwa bara uru na njikwa oke ibu.

Nkwenye nke Semeglutide maka oke ibu site na ndị na-ahụ maka iwu dịka FDA na-egosi oge ọhụrụ na usoro ọgwụ na-abịaru nso na njikwa ibu. Agbanyeghị, ọ dị mkpa icheta na Semeglutide abụghị ngwọta anwansi kama ọ bụ ihe mgbakwunye siri ike maka mgbanwe mgbanwe ndụ zuru oke.

Dị ka ọ dị na enyemaka ahụike ọ bụla, mkpebi iji Semeglutide maka mbelata ibu kwesịrị ime n'otu n'otu, n'ịtụle ọnọdụ ahụike onye ọrịa n'ozuzu ya, ebumnuche ịbelata ibu, yana ihe egwu na uru ndị nwere ike. Ndị na-ahụ maka ahụike na-arụ ọrụ dị oke mkpa n'ịduzi ndị ọrịa site na usoro ime mkpebi a na ịhụ na ojiji nke ọgwụ ahụ dị mma ma dị mma.

Na-ele anya n'ihu, nchọpụta na-aga n'ihu na-aga n'ihu na-achọpụta mmetụta dị ogologo oge nke Semeglutide, enwere ike iji ya mee ihe na ọnụ ọgụgụ ndị ọrịa buru ibu, yana ọrụ ọ na-egbochi nsogbu ndị metụtara oke ibu. Dị ka nghọta anyị banyere oke ibu dị ka ọrịa na-adịghị ala ala na-amalite, ọgwụ dị ka Semeglutide na-enye olileanya maka ụzọ ọgwụgwọ dị irè na nke ahaziri iche.

N'ikpeazụ, nkwenye na iji Semeglutide na-eto eto maka ịbelata ibu na-egosi mkpa ọ dị n'ụzọ dị iche iche iji lụso ọrịa oke ibu ọgụ. Site na ijikọta ntinye ọgwụ na mgbanwe ndụ ndụ, nkwado nke mmụọ, na nlekọta ahụike na-aga n'ihu, anyị nwere ike ịrụ ọrụ maka atụmatụ nlekọta ịdị arọ na-adigide ma dị irè maka ndị mmadụ n'otu n'otu na-alụ ọgụ na oke ibu.

Ọ bụrụ na ị nwekwara mmasị na ngwaahịa a ma chọọ ịmatakwu nkọwa ngwaahịa, ma ọ bụ chọọ ịmata maka ngwaahịa ndị ọzọ metụtara, biko nweere onwe gị ịkpọtụrụ. iceyqiang@gmail.com.

References:

1. "Semeglutide: Nyochaa na ụdị ọrịa shuga 2." Ọgwụ ọjọọ, vol. 77, mba. 12, 2017, p. 1345-1358.

2. "Mmetụta nke Semeglutide na arọ ahụ na ndị ọrịa nwere ụdị ọrịa shuga 2." Nlekọta ọrịa shuga, vol. 41, mba. 2, 2018, p. 259-261 .

3. "Nchekwa ogologo oge na arụmọrụ nke Semeglutide maka ọgwụgwọ oke ibu." Akwụkwọ akụkọ New England nke Medicine, vol. 384, mba. 4, 2021, p. 335-347 .

4. "Ọrụ nke GLP-1 Nnabata Agonists na arọ Management: A lekwasịrị anya na Semeglutide." Nyocha oke ibu, vol. 21, mba. 4, 2020, peeji 1-15 .

5. "Semeglutide maka Mbelata ibu: Nleba anya sitere na nnwale ụlọ ọgwụ." Akwụkwọ akụkọ nke oke ibu na ọgwụgwọ ibu ibu, vol. 8, mba. 3, 2019, peeji 1-5.

6. "Ntụle ntụle nke Semeglutide na ndị ọzọ GLP-1 Analogs na Arọ ọnwụ Therapy." Ọrịa shuga mellitus, ọrịa metabolic na oke ibu: ebumnuche na ọgwụgwọ, vol. 13, 2020, p. 2161-2171.

7. "Nchekwa na nnabata nke Semeglutide na ndị ọrịa nwere oke ibu." Echiche ndị ọkachamara na nchekwa ọgwụ, vol. 19, mba. 5, 2020, p. 571-580 .

8. "Ọdịnihu nke ọgwụgwọ oke ibu: enwere ike nke Semeglutide na ọgwụgwọ ndị ọzọ na-apụta." Ọrịa shuga Lancet & Endocrinology, vol. 8, mba. 6, 2020, p. 473-485 .

9. "Echere ndị ọrịa na iji Semeglutide maka mbelata ibu." Mmasị ndị ọrịa na nrube isi, vol. 14, 2020, p. 1439-1449 .

10. "Ntụle usoro iwu maka nkwenye nke Semeglutide maka ihe ngosi nkwụsị ibu." Clinical Pharmacology & Therapeutics, vol. 107, mba. 4, 2020, p. 826-834 .