Ihe ọmụma
Silver sulfadiazine bụ ihe na-ahụ maka nje na-egbu egbu nke ejirila na-agwọ ọnya ọkụ kemgbe ọtụtụ iri afọ. Ọ bụ ezie na a maara nke ọma maka ịdị irè ya megide nje nje, enwere mmasị na-eto eto na ngwa ya nwere ike ibute ọrịa fungal. Nke a blog post na-enyocha ihe onwunwe nke ọlaọcha sulfadiazine ntụ ntụ na ọrụ ọ ga-ekwe omume n'ịchịkwa ọrịa fungal, na-aza ajụjụ ụfọdụ a na-ajụkarị na inye nghọta dabere na nyocha ugbu a na ahụmahụ ụlọ ọgwụ.
Kedu ihe bụ Silver Sulfadiazine Powder na kedu ka ọ si arụ ọrụ?
Silver sulfadiazine ntụ ntụ bụ ngwakọta antimicrobial sịntetik nke na-ejikọta ihe antimicrobial nke ọlaọcha na sulfonamide ọgwụ nje sulfadiazine. Ngwakọta a na-emepụta ihe nwere ike ime ihe bụ isi ihe na nlekọta ọkụ kemgbe 1960s. Usoro ọrụ nke sulfadiazine ọlaọcha nwere ọtụtụ akụkụ, na-eme ka ọ bụrụ onye na-adọrọ mmasị maka ngwa nje dị iche iche, gụnyere iji ọgwụ nje mee ihe.
Usoro izizi nke sulfadiazine ọlaọcha na-agụnye ntọhapụ nke ion ọla ọcha na ngwa ngwa site na ogige ahụ. Iions ọlaọcha ndị a na-emekọrịta ihe na akpụkpọ anụ nke microorganisms, na-akpaghasị nhazi na ọrụ ha. Mmekọrịta a na-eduga na mgbochi nke DNA replication na protein njikọ, n'ikpeazụ na-ebute ọnwụ cell. A na-edepụta nke ọma ọrụ ion ọlaọcha megide nje bacteria, gụnyere ma ụdị gram-positive na gram-negative.
Na mgbakwunye na mmetụta antimicrobial ya kpọmkwem, sulfadiazine ọlaọcha na-egosipụtakwa ihe mgbochi mkpali. Omume abụọ a na-eme ka ọ baa uru na nlekọta ọnya, ebe ijikwa ma ọrịa na mbufụt dị oke mkpa maka ọgwụgwọ kachasị mma. Ngwakọta ahụ na-emepụta ihe mgbochi nchebe n'elu ọnya ahụ, na-emepụta gburugburu ebe obibi nke na-adịghị mma maka uto microbial ma na-enye ohere maka ịmaliteghachi anụ ahụ.
Njirimara pụrụ iche nke ọlaọcha sulfadiazine ntụ ntụ emeela ka ndị nchọpụta chọpụta ike ya karịa nje nje. Ikike ya ịkpaghasị membranes cell na igbochi usoro cellular na-egosi na ọ nwekwara ike ịdị irè megide nje fungal. Fungi, dị ka nje bacteria, nwere akpụkpọ anụ cell nke na-adịghị ike maka ọrụ nke ion ọlaọcha, na-eme ka sulfadiazine ọlaọcha bụrụ onye na-ekwe nkwa maka ọgwụgwọ antifungal.
Ọzọkwa, nhazi nke sulfadiazine ọlaọcha dị ka ntụ ntụ na-enye ọtụtụ uru n'ihe gbasara ngwa na nchekwa. Enwere ike itinye ntụ ntụ n'ụzọ dị mfe n'ime usoro nnyefe dị iche iche, dị ka ude, ointments, ma ọ bụ akwa akwa, na-enye ohere maka iji ya mee ihe n'ụdị dị iche iche. Mgbanwe a na nhazi nwere ike itinye aka n'ịdị mma ya n'ịgwọ ọrịa fungal n'ebe dị iche iche anatomical.
Enwere ike iji ntụ ntụ Sulfadiazine Silver gwọọ ọrịa anụ ahụ fungal?
Ọ bụ ezie na ọlaọcha sulfadiazine bụ nke a maara nke ọma maka ihe ndị na-egbu nje ya, e nwere ihe àmà na-eto eto na-egosi na ọ pụkwara ịdị irè megide ụfọdụ ọrịa fungal akpụkpọ. Ihe omume antifungal nke silver sulfadiazine abụrụla isiokwu nke ọtụtụ ọmụmụ, yana nsonaazụ na-ekwe nkwa nke na-enye ohere nyocha ọzọ.
Ọrịa anụ ahụ fungal, dịka nke dermatophytes kpatara (dịka ọmụmaatụ, mgbanaka mgbanaka, ụkwụ onye na-eme egwuregwu) ma ọ bụ yists (dịka ọmụmaatụ, ụdị Candida), bụ ọnọdụ akpụkpọ anụ nkịtị nke nwere ike isi ike ịgwọ ya. Ikike nke sulfadiazine ọlaọcha na-emepụta ihe mgbochi na akpụkpọ ahụ yana ọrụ antimicrobial nke sara mbara na-eme ka ọ bụrụ onye na-adọrọ mmasị maka ijikwa ọrịa ndị a.
Ihe omumu in vitro egosila mmetụta antifungal nke silver sulfadiazine megide ụdị fungal dị iche iche. Dịka ọmụmaatụ, nyocha egosila na sulfadiazine ọlaọcha na-egosipụta ọrụ mgbochi megide Candida albicans, ihe na-akpatakarị ọrịa fungal elu. A kwenyere na usoro nke ime ihe megide fungi yiri mmetụta ya na nje bacteria, gụnyere mmebi nke akpụkpọ ahụ cell na nnyonye anya na usoro cellular.
Nleba anya n'ụlọọgwụ enyewokwa ụfọdụ ihe akaebe maka uru mgbochi fungal nke silver sulfadiazine nwere ike. N'ọnọdụ ebe ọrịa fungal na-agbagwoju anya ọnya ọkụ ma ọ bụ mmerụ ahụ akpụkpọ anụ ndị ọzọ, a kọwawo itinye ọlaọcha sulfadiazine iji jikwaa ma nchịkwa nje na fungal nke ọma. Omume abụọ a bara uru karịsịa na gburugburu ọnya dị mgbagwoju anya ebe ọtụtụ ụdị microorganisms nwere ike ịnọ.
Otú ọ dị, ọ dị mkpa iburu n'obi na n'agbanyeghị nchoputa ndị a na-agba ume, iji ọlaọcha sulfadiazine mee ihe maka ọrịa anụ ahụ fungal abụghị usoro ọgwụgwọ ọkọlọtọ. Imirikiti ntuziaka ụlọ ọgwụ ka na-akwado ndị na-ahụ maka ọgwụ mgbochi ọdịnala ka ọ bụrụ ọgwụgwọ mbụ maka ọrịa fungal. A ka na-enyocha ọrụ nke sulfadiazine ọlaọcha nwere ike ime n'ọnọdụ a, a na-achọkwa nnwale ụlọ ọgwụ zuru oke iji gosipụta nrụpụta ọrụ ya na profaịlụ nchekwa ya kpọmkwem maka ọrịa fungal.
Otu uru dị n'iji ọlaọcha sulfadiazine ntụ ntụ maka ọrịa anụ ahụ fungal, ọ bụrụ na egosipụtara na ọ dị irè, ga-abụ ọrụ ya sara mbara. Nke a nwere ike ịba uru karịsịa n'ọnọdụ ebe a na-amataghị nje nje ozugbo ma ọ bụ n'ọrịa agwakọtara nke metụtara ma nje bacteria na fungi. Na mgbakwunye, ihe mgbochi na-akpụ akpụ nke sulfadiazine ọlaọcha nwere ike inye aka chebe akpụkpọ ahụ emetụtara site na mmetọ ọzọ ma kwalite ọgwụgwọ.
Kedu otu Silver Sulfadiazine Powder si atụnyere ọgwụgwọ antifungal ọdịnala?
atụnyere ọlaọcha sulfadiazine ntụ ntụ na ọgwụgwọ antifungal ọdịnala bụ mpaghara nyocha na-akpali akpali nke na-egosipụta ma uru ndị nwere ike ime na njedebe ugbu a nke iji onyinye a maka ọrịa fungal. Usoro ọgwụgwọ antifungal ọdịnala, dị ka azoles (dịka ọmụmaatụ, fluconazole, itraconazole), polyenes (dịka, nystatin), na allylamines (dịka, terbinafine), bụ ihe bụ isi na njikwa ọrịa fungal kemgbe ọtụtụ afọ. Ndị ọrụ ndị a nwere profaịlụ nrụpụta arụ ọrụ nke ọma yana usoro a kapịrị ọnụ nke ime ihe megide akụkụ sel fungal.
Silver sulfadiazine, n'aka nke ọzọ, na-enye ụzọ dị iche iche maka ọgwụgwọ antifungal. Ọrụ antimicrobial dị obosara nke ụdịdị dị iche iche, nke gbatịrị naanị fungi, nwere ike inye uru na ụfọdụ ọnọdụ ụlọ ọgwụ. Dịka ọmụmaatụ, n'ọnọdụ ebe enwere ihe ize ndụ nke ọrịa nje nje nke abụọ ma ọ bụ ebe ụdị ihe iyi egwu microbial na-edoghị anya, ihe nje bacteria na-egbu egbu na ọlaọcha sulfadiazine nwere ike ịba uru.
Otu n'ime isi ọdịiche dị n'etiti silver sulfadiazine na antifungals ọdịnala dabere na usoro ha si eme. Ọtụtụ ọgwụ mgbochi na-elekwasị anya kpọmkwem akụkụ nke mkpụrụ ndụ fungal, dị ka ergosterol na akpụkpọ ahụ cell ma ọ bụ enzymes na-etinye aka na njikọ mgbidi cell. Silver sulfadiazine, Otú ọ dị, na-eme ihe n'ụzọ sara mbara site na-akpaghasị cell membranes na itinye aka na ọtụtụ cell usoro site na omume nke ion ọlaọcha. Usoro a na-abụghị nke a kapịrị ọnụ nwere ike ime ka ọ ghara ịdị mfe na mmepe nke nguzogide, nke bụ nchegbu na-arịwanye elu na ndị ọrụ antifungal omenala.
Nhazi nke sulfadiazine ọlaọcha dị ka ntụ ntụ nke nwere ike itinye n'ime nkwadebe n'elu na-enye ụfọdụ uru n'ihe gbasara ngwa na nnabata onye ọrịa. Ọtụtụ ọgwụgwọ antifungal ọdịnala na-achọ nchịkwa sistemu ma ọ bụ ngwa n'elu ugboro ugboro. Ọgwụgwọ dabere na sulfadiazine ọlaọcha nwere ike inye nhọrọ dị mma maka ndị ọrịa, ọkachasị ma ọ bụrụ na enwere ike ịhazi ya ka ọ bụrụ nkwadebe na-eme ogologo oge.
Agbanyeghị, ọ dị oke mkpa ịnakwere na arụ ọrụ antifungal nke silver sulfadiazine amụbeghị nke ọma ma ọ bụ kwado ya n'ụlọ ọgwụ dịka ọgwụ antifungal ọdịnala. Mgbe a na-ekwe nkwa, isi ihe akaebe dị ugbu a esibeghị ike nke ọma iji dokwa ọlaọcha sulfadiazine ka ọ bụrụ nnọchi maka ọgwụgwọ ọgwụ mgbochi eguzobere. Ọnwụnwa ụlọ ọgwụ zuru oke ka achọrọ iji tụnyere ịdị irè ya, nchekwa ya na nsonaazụ ogologo oge yana nke ọgwụ mgbochi ọdịnala n'ofe ụdị ọrịa fungal dị iche iche.
Ntụle ọzọ bụ ikike nke sulfadiazine ọlaọcha nke a ga-eji na-ejikọta ya na ndị na-ahụ maka ọgwụ ọdịnala. Usoro ọgwụgwọ nchikota dị otú ahụ nwere ike ime ka ike nke ụzọ abụọ a dịkwuo ike, na-enye mkpuchi antimicrobial emelitere yana ikekwe ibelata ihe ize ndụ nke mmepe nguzogide. Agbanyeghị, echiche a chọrọ nyocha nke ọma iji hụ na nchekwa na nrụpụta ọrụ.
Ọnụ ahịa ọlaọcha sulfadiazine na-efu ma e jiri ya tụnyere ọgwụ mgbochi ọdịnala bụ ihe ọzọ na-achọ ka a tụlee ya. Ọ bụ ezie na ọlaọcha sulfadiazine ntụ ntụ n'onwe ya dị ọnụ ala, ọnụ ahịa ọgwụgwọ n'ozuzu ga-adabere na ihe ndị dị ka nhazi, ugboro ngwa, na oge ọgwụgwọ achọrọ iji nweta mkpebi ụlọ ọgwụ.
N'ikpeazụ, mgbe ọlaọcha sulfadiazine ntụ ntụ na-egosi nkwa dị ka ihe nwere ike ime ka ọ bụrụ onye na-ahụ maka ọgwụ nje, ọ na-eje ozi ugbu a dị ka usoro nkwado kama ịbụ nnọchi anya maka ọgwụgwọ antifungal ọdịnala. Ngwongwo ya pụrụ iche na usoro omume ya na-enye ohere dị egwu maka mmepe n'ọdịnihu na ọgwụgwọ antifungal, ọkachasị n'ọnọdụ ebe a na-achọsi ike ọrụ antimicrobial sara mbara. Ka nyocha na mpaghara a na-aga n'ihu, anyị nwere ike ịhụ ọlaọcha sulfadiazine na-arụ ọrụ na-arịwanye elu na njikwa nke ọrịa fungal, ma ọ bụ dị ka ọgwụgwọ kwụ ọtọ ma ọ bụ dịka akụkụ nke ọgwụgwọ ngwakọta.
Ọ bụrụ na ị nwekwara mmasị na ngwaahịa a ma chọọ ịmatakwu nkọwa ngwaahịa, ma ọ bụ chọọ ịmata maka ngwaahịa ndị ọzọ metụtara, biko nweere onwe gị ịkpọtụrụ. iceyqiang@aliyun.com.
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