Kedu ihe ndị na-arụ ọrụ na Carbocysteine ​​​​powder?

Carbocysteine ​​​​na ntụ ntụ, ihe na-emepụta ọgwụ, bụ nke a maara nke ọma maka ihe onwunwe mucolytic ya, na-enyere aka na nkwụsị nke imi na akụkụ iku ume. Nke a na-eme ka ọ bụrụ ihe a na-ahụkarị na ọgwụ ndị a na-eji agwọ ọnọdụ ndị dị ka ọrịa na-adịghị ala ala obstructive pulmonary (COPD), bronchitis, na cystic fibrosis. Ịghọta ihe ndị na-arụ ọrụ na Carbocysteine ​​​​uzuzu dị oké mkpa maka ndị ọrịa na ndị na-ahụ maka ahụike ka ha mee mkpebi ziri ezi banyere iji ya eme ihe.

Isi ihe na-arụ ọrụ na Carbocysteine ​​​​uzuzu bụ S-carboxymethyl-L-cysteine ​​​​, nke a makwaara dị ka carbocisteine ​​​​ma ọ bụ SCMC. Ngwakọta a bụ ihe mgbapụta nke amino acid cysteine, yana otu carboxymethyl jikọtara ya na atom sọlfọ [1]. Usoro kemịkalụ maka Carbocysteine ​​​​bụ C5H9NO4S, ọ nwekwara ịdị arọ molekụla nke 179.19 g/mol.

Ọdịdị Carbocysteine ​​​​bụ isi ihe na-arụ ọrụ ya. Ọnụnọ nke otu sulfhydryl (-SH) na-enye ya ohere imebi njikọ nke disulfide na mucus glycoproteins, na-ebelata viscosity nke imi [2]. A na-emeju omume a site n'ikike ya na-akpali ọrụ cell serous, na-akwalite mmepụta nke imi viscous dị obere.

Na mgbakwunye na akụrụngwa mucolytic ya, achọpụtara Carbocysteine ​​​​nwere mmetụta mgbochi mkpali na antioxidant. Ngwongwo ndị a agbakwunyere na-enye aka na nrụpụta ya n'ozuzu ya na ijikwa ọnọdụ iku ume yana nsogbu ndị ọzọ nwere ike ime [3].

Kedu ọrụ Carbocysteine ​​​​na-arụ na ahụike iku ume?

Carbocysteine ​​​​na-arụ ọrụ dị iche iche na ahụike iku ume, bụ isi site na omume ya dị ka ihe na-atụ anya. Site n'ịkpalata na ịtọpụ imi n'ime ikuku, ọ na-eme ka ịchụpụ ya dị mfe, si otú a na-eme ka ọrụ iku ume dịkwuo elu ma belata ohere nke ibute ọrịa.

Usoro biochemical nke sitere na ya Carbocysteine ​​​​powder na-egosipụta mmetụta ya dị mgbagwoju anya yana ọtụtụ akụkụ:

1. Mucolytic Action: Carbocysteine ​​​​na-agbaji njikọ nke disulfide n'etiti mkpụrụ ndụ mucin, na-ebelata viscosity imi na elasticity. Nke a na-eme ka ọ dịrị ndị ọrịa mfe ikpochapụ imi n'ụzọ ikuku ha [4].

2. Mmetụta Mucoregulatory: Ọ na-enyere aka normalize mmepụta imi site n'ịgbanwe ọrụ nke mkpụrụ ndụ na-emepụta mucus na traktị iku ume. Nke a nwere ike inye aka lebara ma oke imi na ezughị oke [5].

3. Njirimara mgbochi mkpali: E gosipụtara Carbocysteine ​​​​iji belata mmepụta nke cytokines pro-inflammatory ma gbochie neutrophil infiltration na ikuku, nwere ike ibelata mbufụt metụtara ọnọdụ iku ume [6].

4. Mmetụta Antioxidant: Ọ nwere ike ịchụpụ radicals n'efu ma welie ihe nchebe nke anụ ahụ, nke nwere ike inye aka chebe megide mmebi nke nrụgide oxidative na-ebute na ngụgụ [7].

5. Mgbochi Adhesion Bacterial: Ụfọdụ nnyocha na-egosi na Carbocysteine ​​​​nwere ike igbochi ike nke nje bacteria na-arapara na mkpụrụ ndụ epithelial iku ume, nwere ike ibelata ihe ize ndụ nke ọrịa iku ume [8].

Uru Carbocysteine ​​​​na-enye ndị nwere ọnọdụ iku ume dị oke mkpa. N'ime ndị ọrịa nwere COPD, ejirila Carbocysteine ​​​​na-eme ihe mgbe niile na mbelata ugboro ole nke mkpasu iwe, ndụ ndụ ka mma, yana ọrụ ngụgụ ka mma [9]. Maka ndị nwere bronchitis na-adịghị ala ala, ọ nwere ike inye aka belata mgbaàmà dịka ụkwara na ihe isi ike na-atụ anya.

Clinical akaebe na-akwado iji Carbocysteine ​​​​powder bara uru. Nnyocha meta nke nnwale ndị a na-achịkwaghị nke ọma chọpụtara na iji Carbocysteine ​​​​dị ogologo oge na ndị ọrịa COPD belatara ihe egwu nke nnukwu mkpasu iwe na ogo ndụ ka mma [10]. Nnyocha ọzọ gosipụtara ịdị irè ya n'ibelata ugboro ole oyi na-enwekarị na nsogbu ndị yiri ya na ụmụaka nwere ọrịa iku ume ugboro ugboro [11].

Kedu ka ntụ ntụ Carbocysteine ​​​​dị iche na ndị ọrụ Mucolytic ndị ọzọ?

Ọ bụ ezie na a maara Carbocysteine ​​​​maka njirimara mucolytic ya, ọ bụghị naanị ya nwere mmetụta dị otú ahụ. Ndị ọrụ mucolytic ndị ọzọ na-agụnye N-acetylcysteine ​​​​(NAC), bromhexine, na erdosteine ​​​​. Nke ọ bụla n'ime ogige ndị a nwere njirimara pụrụ iche nke na-ekewa ya na Carbocysteine ​​​​:

1. Ọdịdị kemịkalụ: Carbocysteine ​​​​(C5H9NO4S) dị iche na NAC (C5H9NO3S) na ọnụnọ nke otu carboxyl ọzọ. Ọdịiche dị nro a na-emetụta usoro omume ha na ọgwụ ọgwụ [12].

2. Mechanism of Action: Ọ bụ ezie na ma Carbocysteine ​​​​na NAC na-agbaji agbụ disulfide na imi, Carbocysteine ​​​​ nwekwara mmetụta pụtara ìhè na mmepụta na ihe mejupụtara. NAC, n'aka nke ọzọ, nwere mmetụta antioxidant dị ike karị [13].

3. Mmalite na Ogologo oge nke Omume: Carbocysteine ​​​​na-enwekarị mmalite nke nta nke nta mana ogologo oge nke omume ma e jiri ya tụnyere NAC, nke nwere ike iduga ọdịiche dị na usoro doses [14].

4. Profaịlụ Mmetụta Mmetụta: Carbocysteine ​​​​n'ozuzu nwere profaịlụ mmetụta dị mma karịa ma e jiri ya tụnyere ụfọdụ mucolytics ndị ọzọ, na-enwe nsogbu mgbagwoju anya nke eriri afọ [15].

5. Mmetụta ndị ọzọ: N'adịghị ka bromhexine, bụ nke na-arụ ọrụ dị ka mucolytic, Carbocysteine ​​​​nwere ihe ndị ọzọ na-egbochi mkpali na antioxidant nke nwere ike inye aka na njedebe ya na ọnọdụ iku ume [16].

Njirimara pụrụ iche nke Carbocysteine ​​​​na-eme ka ọ bụrụ nhọrọ kachasị mma na ụfọdụ ọnọdụ ụlọ ọgwụ. Dịka ọmụmaatụ, ogologo oge ọ na-arụ ọrụ na-eme ka ọ dị mma maka ịṅụ ọgwụ otu ugboro kwa ụbọchị na ụfọdụ ndị ọrịa, nwere ike ime ka ọ dịkwuo mma. Ngwakọta ya nke mucolytic, mgbochi mkpali, na ihe antioxidant na-eme ka ọ baa uru karịsịa na ọnọdụ iku ume na-adịghị ala ala ebe ọtụtụ usoro pathological na-egwu [17].

Enwere ike iji ntụ ntụ Carbocysteine ​​mee ihe maka ọnọdụ Ewezuga nsogbu iku ume?

Ọ bụ ezie na a maara nke ọma maka iji ya na ahụike iku ume, nchọpụta ekpughere ngwa ndị nwere ike Carbocysteine ​​​​na ntụ ntụ na ọnọdụ ahụike ndị ọzọ. Ebe ọmụmụ ihe ndị a na-apụta na-egosipụta ịdị iche iche nke ogige a:

1. Otitis Media: Carbocysteine ​​egosila nkwa na ọgwụgwọ otitis media na effusion, ọnọdụ a na-ahụkarị na ụmụaka. Ngwongwo mucolytic ya nwere ike inye aka kpochapu mmiri site na ntị etiti, nwere ike ibelata mkpa ịwa ahụ [18].

2. Gastroprotection: Ụfọdụ nnyocha na-egosi na Carbocysteine ​​​​nwere ike inwe mmetụta gastroprotective, nke nwere ike ibelata mmebi nke mucosal gastric na-akpata site na ọgwụ ndị na-abụghị steroidal anti-inflammatory (NSAIDs) [19].

3. Mgbachi imi: Mmetụta mucoregulatory nke Carbocysteine ​​​​nwere ike ịba uru n'ịchịkwa nchichi imi jikọtara ya na ọnọdụ ndị dị ka rhinosinusitis [20].

4. Ọrịa Anya Akọrọ: Nnyocha mbụ na-egosi na Carbocysteine ​​​​nwere ike inye aka melite nkwụsi ike ihe nkiri anya mmiri ma belata mgbaàmà na ndị ọrịa nwere ọrịa anya nkụ [21].

5. Mgbochi ụda olu: Njirimara mucolytic na mgbochi mkpali na-eme ka Carbocysteine ​​​​bụ ọgwụgwọ mgbakwunye na ijikwa ụfọdụ nsogbu ụda olu [22].

Ọ bụ ezie na ngwa ndị a na-egosi nkwa, ọ dị mkpa iburu n'obi na ọtụtụ ka nọ na mmalite nke nyocha. Ọnwụnwa ụlọọgwụ sara mbara ka achọrọ iji gosi n'ụzọ zuru ezu ịdị irè na nchekwa nke Carbocysteine ​​​​na ọnọdụ ndị a na-abụghị iku ume.

mmechi

Carbocysteine ​​​​na ntụ ntụ, ya na ihe na-arụ ọrụ S-carboxymethyl-L-cysteine ​​​​na ụzọ mbụ nke ọgwụgwọ mucolytic, na-enye uru dị ukwuu maka ahụike iku ume. Ngwongwo ya pụrụ iche, gụnyere mucolytic, mucoregulatory, mgbochi mkpali, na mmetụta antioxidant, na-ekewa ya na ndị ọrụ ndị ọzọ ma na-enye aka na nrụpụta ya na njikwa ọnọdụ dịka COPD na bronchitis na-adịghị ala ala.

Ngwa ndị nwere ike ime nke Carbocysteine ​​​​gbatịrị n'akụkụ nsogbu nke iku ume, yana nyocha na-apụta na-egosi uru ọ ga-ekwe omume na otolaryngology, gastroenterology, na ophthalmology. Ngwa ndị a dị iche iche na-emesi ike dị iche iche nke onyinye a ma mee ka ọ dị mkpa ka a nọgide na-eme nchọpụta iji chọpụta n'ụzọ zuru ezu ikike ọgwụgwọ ya.

Dị ka ọ dị n'ọgwụgwọ ọ bụla, ịghọta ihe ndị na-arụ ọrụ na ojiji nke Carbocysteine ​​​​bụ isi ihe na-eme ka ike ọgwụgwọ ya dị irè. Ndị na-ahụ maka ahụike kwesịrị ịtụle ihe pụrụ iche nke Carbocysteine ​​​​mgbe ị na-ahọrọ ọgwụgwọ maka ndị ọrịa nwere ọnọdụ iku ume na nsogbu ndị ọzọ ebe usoro omume ya nwere ike ịba uru.

Ntuziaka nyocha n'ọdịnihu nwere ike ịgụnye ịgagharị usoro ọgwụgwọ kachasị mma, nyochaa mmetụta mmekọ ọnụ na ọgwụ ndị ọzọ, na ime nnukwu ule ụlọ ọgwụ maka ngwa ya na-abụghị iku ume. Ka nghọta anyị banyere usoro Carbocysteine ​​​​na-aga n'ihu na-eto eto, otu ahụ nwekwara ike ịbụ ọrụ ya na omume ụlọ ọgwụ, nke nwere ike ịnye ọgwụgwọ ọhụrụ maka ọtụtụ ndị ọrịa.

Ọ bụrụ na ị nwekwara mmasị na ngwaahịa a ma chọọ ịmatakwu nkọwa ngwaahịa, ma ọ bụ chọọ ịmata maka ngwaahịa ndị ọzọ metụtara, biko nweere onwe gị ịkpọtụrụ. iceyqiang@gmail.com.

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