Kedu ihe ị ga-ezere mgbe ị na-ewere ntụ ntụ Ezetimibe?

Ezetimibe ntụ ntụ bụ usoro ọgwụ eji eme ka ọkwa cholesterol dị ala site na igbochi nnabata cholesterol na nri. Ọ bụ nke otu ọgwụ a na-akpọ cholesterol absorption inhibitors ma na-arụ ọrụ site n'igbochi eriri afọ ka ọ ghara ịmịkọrọ cholesterol, si otú ahụ na-ebelata ọkwa ya n'ọbara [1]. Ọ bụ ezie na ọ nwere ike ịbụ akụkụ dị irè nke usoro nchịkwa cholesterol, e nwere ihe ụfọdụ ị ga-atụle mgbe ị na-aṅụ ọgwụ a iji hụ na ọ dị irè na nchekwa ya.

A na-edokarị Ezetimibe ntụ ntụ maka ndị ọrịa nwere hyperlipidemia nke mbụ, hyperlipidemia agwakọta, ma ọ bụ hypercholesterolemia homozygous familial. Enwere ike iji ya naanị ya ma ọ bụ jikọtara ya na ihe ndị ọzọ na-ebelata lipid, karịsịa statins [2]. Dị ka ọ dị n'ọgwụgwọ ọ bụla, ọ dị oke mkpa ịghọta mmekọrịta ndị nwere ike ime, mmetụta ndị dị n'akụkụ, na echiche ndụ iji bulie uru ya ma na-ebelata ihe egwu.

Isiokwu a ga-atụle ihe ị ga-ezere mgbe ị na-ewere Ezetimibe ntụ ntụ, gụnyere ihe gbasara nri, mmekọrịta ọgwụ nwere ike ime, na mgbanwe ndụ. Site n'ịmara ihe ndị a, ndị ọrịa nwere ike ịkwalite ọgwụgwọ ha wee nweta nsonaazụ ka mma na ijikwa ọkwa cholesterol ha.

Nri ọ bụla nwere ike igbochi ịdị mma nke ntụ ntụ Ezetimibe?

Ntinye na nrụpụta nke Ezetimibe Powder nwere ike imetụta ihe oriri dị iche iche. Ịghọta mmekọrịta ndị a dị oké mkpa maka ndị ọrịa ka ha na-ebuli uru dị na ọgwụ ha.

1. Nri dị oke abụba:

ewe Ezetimibe ntụ ntụ na nri nwere oke abụba nwere ike imetụta nnabata ya. Nnyocha egosila na nri nwere nnukwu abụba nwere ike ịbawanye bioavailability nke ezetimibe, nke nwere ike ibute mkpokọta plasma dị elu [3]. Ọ bụ ezie na nke a apụtaghị na ibelata ịdị irè ọgwụ ahụ, ọ nwere ike ịgbanwe ọgwụ ọgwụ ya. A na-adụ ndị ọrịa ọdụ ka ha na-ewere ntụ ntụ Ezetimibe mgbe niile gbasara nri - ma ọ bụrụ na ọ na-eri nri mgbe niile ma ọ bụ na-enweghị nri mgbe niile - iji nọgide na-enwe usoro nnabata.

2. Mkpụrụ osisi grepu na ihe ọṅụṅụ mkpụrụ osisi grepu:

N'adịghị ka ọgwụ ndị ọzọ na-ebelata cholesterol, karịsịa statins, Ezetimibe Powder adịghị ka ọ na-enwe mmekọrịta dị ukwuu na mkpụrụ osisi grepu ma ọ bụ mkpụrụ osisi grepu [4]. Agbanyeghị, ndị ọrịa na-ewere Ezetimibe yana statins ka kwesịrị ịkpachara anya maka iri mkpụrụ osisi grepu, n'ihi na ọ nwere ike imetụta metabolism nke ọtụtụ ọgwụ statin.

3. Nri nwere eriri:

Ọ bụ ezie na nri nwere eriri dị elu na-abakarị uru maka ahụike obi, oke oke oriri nke eriri soluble (dị ka psyllium) nwere ike igbochi nnabata nke Ezetimibe. Ndị ọrịa kwesịrị ịnọgide na-eri nri kwesịrị ekwesị ma gakwuru onye na-ahụ maka ahụike ha ma ọ bụrụ na ha na-eme atụmatụ ịbawanye oriri fiber ha nke ukwuu [5].

4. Mmanya:

Ịṅụ mmanya na-aba n'anya adịghị egosi na ọ na-emekọrịta ihe ozugbo na ntụ ntụ Ezetimibe. Otú ọ dị, ịṅụbiga mmanya ókè nwere ike ịkwalite ọkwa triglyceride ma nwee ike igbochi mmetụta cholesterol na-ebelata nke ọgwụ ahụ. A dụrụ ndị ọrịa ọdụ ka ha belata ịṅụ mmanya na-aba n'anya dịka akụkụ nke atụmatụ ahụike obi ha n'ozuzu ha [6].

5. Oge iri nri:

Ọ bụ ezie na enwere ike iji Ezetimibe were ma ọ bụ na-enweghị nri, idowe nkwụsi ike n'oge n'ihe metụtara nri nwere ike inye aka hụ na nnabata na-aga n'ihu. Ụfọdụ ndị ọrịa na-ahụ na ọ na-enye aka ịṅụ ọgwụ ahụ n'otu oge kwa ụbọchị, ma ọ bụ jiri nri ụtụtụ ma ọ bụ na mgbede, dabere na usoro ha na-eme na ndụmọdụ ndị nlekọta ahụike [7].

Ọ dị mma iji ọgwụ ndị ọzọ maka Cholesterol were ntụ ntụ Ezetimibe?

Ezetimibe ntụ ntụ A na-enyekarị ọgwụ ndị ọzọ na-ebelata cholesterol, karịsịa statins, iji nweta mbelata dị ukwuu na ọkwa LDL cholesterol. Agbanyeghị, ọ dị mkpa ịtụle mmekọrịta nwere ike na ọgwụ ndị ọzọ nwere ike imetụta ọkwa cholesterol ma ọ bụ nwee mmetụta dị n'akụkụ.

1. Ngwakọta na Statins:

Nchikota Ezetimibe na statins ka enyochala nke ukwuu ma a na-ewerekarị na ọ dị mma ma dị irè. Nchikota a nwere ike bute mbelata nke LDL cholesterol karia ogwu ozo [8]. Otú ọ dị, a ga-enyocha ndị ọrịa maka mmetụta ndị nwere ike ime, karịsịa ihe mgbaàmà metụtara muscle, nke nwere ike ime na ọgwụgwọ statin.

2. Bile Acid Sequestrants:

Mgbe ejiri ya na sequestrants bile acid dị ka cholestyramine, a ga-ewere Ezetimibe opekata mpe awa 2 tupu ma ọ bụ awa 4 ka emechara usoro bile acid. Oge a na-enyere aka igbochi onye sequestrant ka ọ ghara ijikọ Ezetimibe ma belata mmịnye ya [9].

3. Fibrates:

Ijikọta Ezetimibe na fibrates, dị ka fenofibrate, nwere ike ịdị irè n'ịchịkwa dyslipidemia agwakọta. Agbanyeghị, ngwakọta a nwere ike ịbawanye ohere nke nkume gallstone na ekwesịrị iji ya n'okpuru nlekọta ahụike [10].

4. Ọgwụ mgbochi:

Ndị ọrịa na-aṅụ ọgwụ mgbochi ọbara, dị ka warfarin, kwesịrị ileba anya nke ọma mgbe ịmalite ma ọ bụ gbanwee ọgwụgwọ Ezetimibe. Ọ bụ ezie na mmekọrịta chiri anya abụghị ihe a na-ahụkarị, mgbanwe na ọkwa cholesterol nwere ike imetụta metabolism nke ụfọdụ anticoagulants [7].

5. Ọgwụ ndị ọzọ:

Ezetimibe nwere mmekọrịta ọgwụ ole na ole amaara ma e jiri ya tụnyere ụfọdụ ọgwụ ndị ọzọ na-ebelata cholesterol. Agbanyeghị, ndị ọrịa kwesịrị ịgwa onye na-ahụ maka ahụike ha mgbe niile gbasara ọgwụ niile, mgbakwunye, na ngwaahịa ahịhịa ha na-ewere iji hụ na enweghị mmekọrịta ọ bụla.

Kedu mgbanwe ndụ nke ekwesịrị ịtụle mgbe ị na-eji ntụ ntụ Ezetimibe?

Na mgbakwunye na ọgwụ, ime ụfọdụ mgbanwe ndụ nwere ike welie irè nke Ezetimibe ntụ ntụ ma na-enye aka na ahụike obi n'ozuzu ya. Mgbanwe ndị a nwere ike inyere ndị ọrịa aka inweta nsonaazụ ka mma n'ịchịkwa ọkwa cholesterol ha ma belata ihe ize ndụ nke ọrịa obi.

1. Mgbanwe nri:

• Nweta nri na-eme ka obi dị mma nke nwere mkpụrụ osisi, akwụkwọ nri, ọka zuru oke na protein ndị na-esighị ike.
• Belata oriri nke juputara na abụba trans, nke nwere ike ibuli ọkwa LDL cholesterol.
• Mụbaa iri nri ndị nwere eriri soluble dị ka oat, agwa, na lentil, nke nwere ike inye aka belata cholesterol.
• Tụlee itinye sterols osisi na stanols, nke a na-ahụ na ụfọdụ nri siri ike, nke nwere ike imeju mmetụta mbelata cholesterol nke Ezetimibe [11].

2. Mmega ahụ mgbe niile:

• Soro na opekata mpe nkeji 150 nke mmemme ikuku ikuku siri ike ma ọ bụ nkeji 75 nke ike ikuku ike kwa izu.
• Gụnye mmega ahụ ọzụzụ nguzogide opekata mpe ugboro abụọ n'izu iji kwalite ahụike obi niile.
• Mmega ahụ mgbe niile nwere ike inye aka bulie ọkwa cholesterol HDL ma melite arụmọrụ ọgwụ na-ebelata cholesterol [12].

3. Njikwa ibu:

• Nọgide na-enwe ahụ ike ma ọ bụ rụọ ọrụ maka ịbelata ibu ma ọ bụrụ oke ibu ma ọ bụ oke ibu.
• Ọbụlagodi oke ibu dị arọ nwere ike ịba uru dị ukwuu na profaịlụ lipid yana ahụike obi niile.

4. Ịkwụsị ịṅụ sịga:

• Ọ bụrụ na ọdabara, kwụsị ise siga ma ọ bụ zere ikpughe anwụrụ ọkụ.
• Ịṅụ sịga nwere ike ibelata ọkwa cholesterol HDL ma mee ka ohere nke ọrịa obi dịkwuo elu.

5. Nlekọta nchekasị:

• Tinye usoro mbelata nchekasị dị ka ntụgharị uche, yoga, ma ọ bụ mmega iku ume miri emi.
• Nchegbu na-adịghị ala ala nwere ike imetụta ọkwa cholesterol na ahụike obi zuru oke.

6. Nleba ahụike mgbe niile:

• Gaa na nhọpụta ndị akwadoro iji nyochaa ọkwa cholesterol wee chọpụta ịdị irè ọgwụgwọ Ezetimibe.
• Soro ndị na-ahụ maka ahụike kparịta mmetụta ọ bụla ma ọ bụ nchegbu ọ bụla.

7. Nkwenye ọgwụ:

• Were Ezetimibe ntụ ntụ dịka edepụtara ya, n'otu oge kwa ụbọchị.
• Jiri usoro ncheta ma ọ bụ ngwa iji hụ na ị na-aṅụ ọgwụ na-agbanwe agbanwe.

8. Mbelata mmanya na-aba n'anya:

• Ọ bụrụ na ị na-aṅụ mmanya na-aba n'anya, mee ya nke ọma (ihe ruru otu mmanya kwa ụbọchị maka ụmụ nwanyị na ihe ọṅụṅụ abụọ kwa ụbọchị maka ụmụ nwoke).
• Ịṅụbiga mmanya ókè nwere ike ịkwalite ọkwa triglyceride ma gbochie ịdị irè nke ọgwụgwọ na-ebelata cholesterol.

mmechi

ewere Ezetimibe ntụ ntụ dị ka akụkụ nke usoro zuru oke maka njikwa cholesterol nwere ike ịba uru nke ukwuu. Site n'ichebara mmekọrịta dị n'ihe oriri, nchịkọta ọgwụ nwere ike ime, na mgbanwe ndụ dị mkpa, ndị mmadụ n'otu n'otu nwere ike ịbawanye uru ọgwụgwọ a ma na-ebelata ihe egwu.

Ezetimibe ntụ ntụ na-enye nhọrọ dị mkpa maka ndị ọrịa na-agbasi mbọ ike ịchịkwa ọkwa cholesterol ha site na nri, mgbatị ahụ, na ọgwụ ndị ọzọ naanị. Usoro ihe omume ya pụrụ iche, na-elekwasị anya nnabata cholesterol n'ime eriri afọ, na-emeju atụmatụ ndị ọzọ na-ebelata cholesterol ma nwee ike ibute mmụba dị ukwuu na profaịlụ lipid.

Otú ọ dị, ọganihu nke ọgwụgwọ Ezetimibe na-adabere ọ bụghị nanị na ọgwụ n'onwe ya kamakwa n'ụzọ zuru ezu nke onye ọrịa na-agbaso ahụike obi. Site n'izere nri ndị nwere oke abụba mgbe ị na-aṅụ ọgwụ, ịmara na enwere ike ịmekọrịta ọgwụ ndị ọzọ, na ịnakwere mgbanwe ndụ ahụike obi, ndị ọrịa nwere ike ịkwalite usoro nlekọta cholesterol ha.

Ọ dị mkpa icheta na ijikwa cholesterol bụ nkwa na-adịte aka. Ndị ọrịa kwesịrị ịrụkọ ọrụ ọnụ na ndị na-ahụ maka ahụike ha ka ha nyochaa ọganihu, dozie ọgwụgwọ dịka ọ dị mkpa, ma dozie nchegbu ọ bụla ma ọ bụ mmetụta ọ bụla ozugbo. Site na nchikota ziri ezi nke ọgwụ, nri, mmega ahụ, na mgbanwe ndụ, ọtụtụ ndị ọrịa nwere ike nweta ma nọgide na-enwe ọkwa cholesterol dị mma, na-ebelata ihe ize ndụ nke ọrịa obi na ime ka ahụike na ọdịmma ha dịkwuo mma.

Ọ bụrụ na ị nwekwara mmasị na ngwaahịa a ma chọọ ịmatakwu nkọwa ngwaahịa, ma ọ bụ chọọ ịmata maka ngwaahịa ndị ọzọ metụtara, biko nweere onwe gị ịkpọtụrụ. iceyqiang@gmail.com.

References:

[1] Kosoglou, T., Statkevich, P., Johnson-Levonas, AO, Paolini, JF, Bergman, AJ, & Alton, KB (2005). Ezetimibe. Clinical pharmacokinetics, 44(5), 467-494.

[2] Phan, BA, Dayspring, TD, & Toth, PP (2012). Ọgwụ Ezetimibe: usoro ihe omume na mmelite ụlọ ọgwụ. Ahụike akwara na njikwa ihe egwu, 8.

[3] Knopp, RH, Gitter, H., Truitt, T., Bays, H., Manion, CV, Lipka, LJ, ... & Veltri, EP (2003). Mmetụta ezetimibe, onye na-egbochi nnabata cholesterol ọhụrụ, na lipids plasma na ndị ọrịa nwere hypercholesterolemia mbụ. Akwụkwọ akụkọ obi European, 24 (8), 729-741.

[4] Reamy, BV, & Stephens, MB (2007). Arụmụka mmekọrịta nke mkpụrụ osisi grepu-ọgwụ: ọrụ nke statins. Dọkịta ezinụlọ America, 76 (2), 190-192.

[5] Brown, L., Rosner, B., Willett, WW, & Sacks, FM (1999). Mmetụta na-ebelata cholesterol nke eriri nri: meta-analysis. Akwụkwọ akụkọ America nke nri nri ụlọ ọgwụ, 69(1), 30-42.

[6] Kloner, RA, & Rezkalla, SH (2007). Ịṅụ mmanya ma ọ bụ ịghara ịṅụ mmanya? Nke ahụ bụ ajụjụ. Mgbasa ozi, 116 (11), 1306-1317.

[7] Davidson, MH (2003). Ezetimibe: nhọrọ ọhụrụ maka ibelata cholesterol. Nyocha ndị ọkachamara banyere ọgwụgwọ ọrịa obi, 1 (1), 11-21.

[8] Ballantyne, CM, Houri, J., Notarbartolo, A., Melani, L., Lipka, LJ, Suresh, R., ... & Ezetimibe Study Group. (2003). Mmetụta ezetimibe jikọtara ya na atorvastatin n'ime ndị ọrịa 628 nwere hypercholesterolemia bụ isi: nnwale a na-atụ anya, nke enweghị usoro, nke kpuru ìsì abụọ. Mgbasa ozi, 107 (19), 2409-2415.

[9] Bays, HE, Moore, PB, Drehobl, MA, Rosenblatt, S., Toth, PD, Dujovne, CA, ... & Ezetimibe Study Group. (2001). Irè na nnabata nke ezetimibe n'ime ndị ọrịa nwere hypercholesterolemia bụ isi: nyocha mkpokọta nke ọmụmụ nke abụọ nke abụọ. Usoro ọgwụgwọ ụlọ ọgwụ, 23 (8), 1209-1230.

[10] McKenney, JM, Farnier, M., Lo, KW, Bays, HE, Perevozkaya, I., Carlson, G., ... & Mitchel, YB (2006). Nchekwa na ịdị irè nke njikwa ogologo oge nke fenofibrate na ezetimibe na ndị ọrịa nwere hyperlipidemia agwakọta. Akwụkwọ akụkọ nke American College of Cardiology, 47(8), 1584-1587.